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Literature summary extracted from

  • Schmidtchen, A.; Pasupuleti, M.; Moergelin, M.; Davoudi, M.; Alenfall, J.; Chalupka, A.; Malmsten, M.
    Boosting antimicrobial peptides by hydrophobic oligopeptide end tags (2009), J. Biol. Chem., 284, 17584-17594.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.19 tagged peptide GKH17 i.e. GKHKNKGKKNGKHNGWK,an antimicrobial peptide, derived from kininogen boosted through end tagging with hydrophobic oligopeptide stretches. Tagging results in enhanced killing of Gram-positive Staphylococcus aureus. Microbicidal potency increases with tag length, also in plasma, and is larger for Trp and Phe stretches than for aliphatic ones, overview Staphylococcus aureus
3.4.21.19 tagged peptide HKH17 i.e. HKHGHGHGKHKNKGKKN,an antimicrobial peptide, derived from kininogen boosted through end tagging with hydrophobic oligopeptide stretches. Tagging results in enhanced killing of Gram-positive Staphylococcus aureus. Microbicidal potency increases with tag length, also in plasma, and is larger for Trp and Phe stretches than for aliphatic ones, overview Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.19 Staphylococcus aureus
-
 strain ATCC 29213
-
3.4.24.29 Staphylococcus aureus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.29 additional information aureolysin does not hydrolyze GKHKNKGKKNGKHNGWK and HKHGHGHGKHKNKGKKN Staphylococcus aureus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.19 V8 proteinase
-
 Staphylococcus aureus
3.4.24.29 Aur
-
 Staphylococcus aureus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.19 37
-
 assay at Staphylococcus aureus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.19 7.4
-
 assay at Staphylococcus aureus