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Literature summary extracted from

  • Chiku, T.; Padovani, D.; Zhu, W.; Singh, S.; Vitvitsky, V.; Banerjee, R.
    H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia (2009), J. Biol. Chem., 284, 11601-11612.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.4.1.1 expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.1 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.4.1.1 Superdex S-200 gel filtration Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.1 L-cystathionine + H2O
-
 Homo sapiens L-cysteine + 2-oxobutanoate + NH3
-
 ?
4.4.1.1 L-cysteine + H2O
-
 Homo sapiens sulfide + NH3 + pyruvate
-
 ?
4.4.1.1 L-cysteine + L-cysteine
-
 Homo sapiens H2S + L-lanthionine
-
 ?
4.4.1.1 L-cystine + H2O
-
 Homo sapiens L-thiocysteine + pyruvate + NH3
-
 ?
4.4.1.1 L-homocysteine + H2O
-
 Homo sapiens NH3 + 2-oxobutanoate + H2S
-
 ?
4.4.1.1 L-homocysteine + L-cysteine
-
 Homo sapiens L-cystathionine + H2S
-
 ?
4.4.1.1 L-homocysteine + L-homocysteine
-
 Homo sapiens L-homolanthionine + H2S
-
 ?
4.4.1.1 L-homoserine + H2O
-
 Homo sapiens H2O + NH3 + 2-oxobutanoate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.4.1.1 CSE
-
 Homo sapiens
4.4.1.1 cysteine desulfhydrase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
4.4.1.1 pyridoxal 5'-phosphate
-
 Homo sapiens