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Literature summary extracted from

  • Wanner, R.M.; Castor, D.; Guethlein, C.; Boettger, E.C.; Springer, B.; Jiricny, J.
    The uracil DNA glycosylase UdgB of Mycobacterium smegmatis protects the organism from the mutagenic effects of cytosine and adenine deamination (2009), J. Bacteriol., 191, 6312-6319.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.2.2.27 genes udgB and ung, phylogenetic analysis Mycolicibacterium smegmatis

Protein Variants

EC Number Protein Variants Comment Organism
3.2.2.27 additional information generation of udgB and ung knockout mutants by allelic replacement techniques. The general mutation frequency is increased in UDG knockout strains, frequencies of A:T to G:C mutations, which may arise through adenine deamination, in the udgB knockout mutant and in the double-knockout mutant are 10fold and 31fold higher that those in the wild-type strain, respectively, overview Mycolicibacterium smegmatis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.2.27 additional information association of Ung with the replication fork Mycolicibacterium smegmatis
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.2.27 additional information Mycolicibacterium smegmatis UdgB removes aberrant bases uracil, from deaminated cytosine, and hypoxanthine, from deaminated adenine, and 5-fluorouracil from DNA with high efficiency ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.2.27 Mycolicibacterium smegmatis
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 genes udgB and ung
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.2.27 additional information UdgB removes aberrant bases uracil, from deaminated cytosine, and hypoxanthine, from deaminated adenine, and 5-fluorouracil from DNA with high efficiency Mycolicibacterium smegmatis ?
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 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.2.27 UdgB
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 Mycolicibacterium smegmatis
3.2.2.27 Ung-type uracil glycosylase
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 Mycolicibacterium smegmatis
3.2.2.27 uracil DNA glycosylase
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 Mycolicibacterium smegmatis

General Information

EC Number General Information Comment Organism
3.2.2.27 malfunction thymidylate synthase inhibition leads to UDG-dependent cell death Mycolicibacterium smegmatis
3.2.2.27 physiological function UdgB from Mycobacterium smegmatis protects this organism against mutagenesis associated with deamination of both cytosine and adenine. Together with Ung-type uracil glycosylase, UdgB also helps attenuate the cytotoxicity of the antimicrobial agent 5-fluorouracil Mycolicibacterium smegmatis