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Literature summary extracted from

  • Rodrigues, M.V.; Borges, N.; Henriques, M.; Lamosa, P.; Ventura, R.; Fernandes, C.; Empadinhas, N.; Maycock, C.; da Costa, M.S.; Santos, H.
    Bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase, the key enzyme for di-myo-inositol-phosphate synthesis in several (hyper)thermophiles (2007), J. Bacteriol., 189, 5405-5412.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.74
-
 Pyrococcus furiosus
2.7.7.74
-
 Thermococcus kodakarensis
2.7.7.74
-
 Aquifex aeolicus
2.7.7.74
-
 Rubrobacter xylanophilus
2.7.7.74 expression in Escherichia coli Archaeoglobus fulgidus
2.7.8.34 expression in Escherichia coli Archaeoglobus fulgidus
2.7.8.34 expression in Escherichia coli Pyrococcus furiosus
2.7.8.34 expression in Escherichia coli Thermococcus kodakarensis
2.7.8.34 expression in Escherichia coli Aquifex aeolicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.74 CTP + 1L-myo-inositol 1-phosphate Archaeoglobus fulgidus the enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments diphosphate + CDP-1L-myo-inositol
-
 ?
2.7.7.74 CTP + 1L-myo-inositol 1-phosphate Pyrococcus furiosus the enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments diphosphate + CDP-1L-myo-inositol
-
 ?
2.7.7.74 CTP + 1L-myo-inositol 1-phosphate Thermococcus kodakarensis the enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments diphosphate + CDP-1L-myo-inositol
-
 ?
2.7.7.74 CTP + 1L-myo-inositol 1-phosphate Aquifex aeolicus the enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments diphosphate + CDP-1L-myo-inositol
-
 ?
2.7.7.74 CTP + 1L-myo-inositol 1-phosphate Rubrobacter xylanophilus the enzyme is involved in biosynthesis of di-myo-inositol 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments diphosphate + CDP-1L-myo-inositol
-
 ?
2.7.8.34 CDP-1L-myo-inositol + 1L-myo-inositol 1-phosphate Archaeoglobus fulgidus the enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments CMP + bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate
-
 ?
2.7.8.34 CDP-1L-myo-inositol + 1L-myo-inositol 1-phosphate Pyrococcus furiosus the enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments CMP + bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate
-
 ?
2.7.8.34 CDP-1L-myo-inositol + 1L-myo-inositol 1-phosphate Thermococcus kodakarensis the enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments CMP + bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate
-
 ?
2.7.8.34 CDP-1L-myo-inositol + 1L-myo-inositol 1-phosphate Aquifex aeolicus the enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments CMP + bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.74 Aquifex aeolicus O67379
-
-
2.7.7.74 Archaeoglobus fulgidus O29976
-
-
2.7.7.74 Pyrococcus furiosus Q8U1Z6
-
-
2.7.7.74 Rubrobacter xylanophilus Q1AWQ0
-
-
2.7.7.74 Thermococcus kodakarensis Q5JDA9
-
-
2.7.8.34 Aquifex aeolicus O67379
-
-
2.7.8.34 Archaeoglobus fulgidus O29976
-
-
2.7.8.34 Pyrococcus furiosus Q8U1Z6
-
-
2.7.8.34 Thermococcus kodakarensis Q5JDA9
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.7.74 partial Archaeoglobus fulgidus
2.7.8.34 partial Archaeoglobus fulgidus
2.7.8.34 partial Pyrococcus furiosus
2.7.8.34 partial Thermococcus kodakarensis
2.7.8.34 partial Aquifex aeolicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.74 CTP + 1L-myo-inositol 1-phosphate the enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments Archaeoglobus fulgidus diphosphate + CDP-1L-myo-inositol
-
 ?
2.7.7.74 CTP + 1L-myo-inositol 1-phosphate the enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments Pyrococcus furiosus diphosphate + CDP-1L-myo-inositol
-
 ?
2.7.7.74 CTP + 1L-myo-inositol 1-phosphate the enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments Thermococcus kodakarensis diphosphate + CDP-1L-myo-inositol
-
 ?
2.7.7.74 CTP + 1L-myo-inositol 1-phosphate the enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments Aquifex aeolicus diphosphate + CDP-1L-myo-inositol
-
 ?
2.7.7.74 CTP + 1L-myo-inositol 1-phosphate the enzyme is involved in biosynthesis of di-myo-inositol 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments Rubrobacter xylanophilus diphosphate + CDP-1L-myo-inositol
-
 ?
2.7.7.74 CTP + 1L-myo-inositol 1-phosphate bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase. The cytidylyltransferase is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The di-myo-inositol-1,3'-phosphate-1'-phosphate synthase domain uses only 1L-myo-inositol 1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-L-myo-inositol and CDP-D-myo-inositol, are recognized as alcohol donors Archaeoglobus fulgidus diphosphate + CDP-1L-myo-inositol structural characterization of products by nuclear magnetic resonance ?
2.7.7.74 CTP + 1L-myo-inositol 1-phosphate bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase. The cytidylyltransferase is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The di-myo-inositol-1,3'-phosphate-1'-phosphate synthase domain uses only 1L-myo-inositol 1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-L-myo-inositol and CDP-D-myo-inositol, are recognized as alcohol donors Pyrococcus furiosus diphosphate + CDP-1L-myo-inositol structural characterization of products by nuclear magnetic resonance ?
2.7.7.74 CTP + 1L-myo-inositol 1-phosphate bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase. The cytidylyltransferase is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The di-myo-inositol-1,3'-phosphate-1'-phosphate synthase domain uses only 1L-myo-inositol 1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-L-myo-inositol and CDP-D-myo-inositol, are recognized as alcohol donors Thermococcus kodakarensis diphosphate + CDP-1L-myo-inositol structural characterization of products by nuclear magnetic resonance ?
2.7.7.74 CTP + 1L-myo-inositol 1-phosphate bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase. The cytidylyltransferase is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The di-myo-inositol-1,3'-phosphate-1'-phosphate synthase domain uses only 1L-myo-inositol 1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-L-myo-inositol and CDP-D-myo-inositol, are recognized as alcohol donors Aquifex aeolicus diphosphate + CDP-1L-myo-inositol structural characterization of products by nuclear magnetic resonance ?
2.7.7.74 CTP + 1L-myo-inositol 1-phosphate no CDP-inositol:inositol-1-phosphate transferase activity detected. myo-Inositol is not a substrate Rubrobacter xylanophilus diphosphate + CDP-1L-myo-inositol structural characterization of products by nuclear magnetic resonance ?
2.7.8.34 CDP-1L-myo-inositol + 1L-myo-inositol 1-phosphate the enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments Archaeoglobus fulgidus CMP + bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate
-
 ?
2.7.8.34 CDP-1L-myo-inositol + 1L-myo-inositol 1-phosphate the enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments Pyrococcus furiosus CMP + bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate
-
 ?
2.7.8.34 CDP-1L-myo-inositol + 1L-myo-inositol 1-phosphate the enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments Thermococcus kodakarensis CMP + bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate
-
 ?
2.7.8.34 CDP-1L-myo-inositol + 1L-myo-inositol 1-phosphate the enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments Aquifex aeolicus CMP + bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate
-
 ?
2.7.8.34 CDP-1L-myo-inositol + 1L-myo-inositol 1-phosphate bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase. The cytidylyltransferase is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The di-myo-inositol-1,3'-phosphate-1'-phosphate synthase domain uses only 1L-myo-inositol 1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-L-myo-inositol and CDP-D-myo-inositol, are recognized as alcohol donors Archaeoglobus fulgidus CMP + bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate
-
 ?
2.7.8.34 CDP-1L-myo-inositol + 1L-myo-inositol 1-phosphate bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase. The cytidylyltransferase is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The di-myo-inositol-1,3'-phosphate-1'-phosphate synthase domain uses only 1L-myo-inositol 1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-L-myo-inositol and CDP-D-myo-inositol, are recognized as alcohol donors Pyrococcus furiosus CMP + bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate
-
 ?
2.7.8.34 CDP-1L-myo-inositol + 1L-myo-inositol 1-phosphate bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase. The cytidylyltransferase is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The di-myo-inositol-1,3'-phosphate-1'-phosphate synthase domain uses only 1L-myo-inositol 1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-L-myo-inositol and CDP-D-myo-inositol, are recognized as alcohol donors Thermococcus kodakarensis CMP + bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate
-
 ?
2.7.8.34 CDP-1L-myo-inositol + 1L-myo-inositol 1-phosphate bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase. The cytidylyltransferase is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The di-myo-inositol-1,3'-phosphate-1'-phosphate synthase domain uses only 1L-myo-inositol 1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-L-myo-inositol and CDP-D-myo-inositol, are recognized as alcohol donors Aquifex aeolicus CMP + bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate
-
 ?
2.7.8.34 CDP-D-myo-inositol + 1L-myo-inositol 1-phosphate bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase. The cytidylyltransferase is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The di-myo-inositol-1,3'-phosphate-1'-phosphate synthase domain uses only 1L-myo-inositol 1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-L-myo-inositol and CDP-D-myo-inositol, are recognized as alcohol donors Pyrococcus furiosus ?
-
 ?
2.7.8.34 CDP-D-myo-inositol + 1L-myo-inositol 1-phosphate bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase. The cytidylyltransferase is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The di-myo-inositol-1,3'-phosphate-1'-phosphate synthase domain uses only 1L-myo-inositol 1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-L-myo-inositol and CDP-D-myo-inositol, are recognized as alcohol donors Thermococcus kodakarensis ?
-
 ?
2.7.8.34 CDP-D-myo-inositol + 1L-myo-inositol 1-phosphate bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase. The cytidylyltransferase is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The di-myo-inositol-1,3'-phosphate-1'-phosphate synthase domain uses only 1L-myo-inositol 1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-L-myo-inositol and CDP-D-myo-inositol, are recognized as alcohol donors Aquifex aeolicus ?
-
 ?
2.7.8.34 CDP-glycerol + 1D-myo-inositol 3-phosphate bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase. The cytidylyltransferase is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The di-myo-inositol-1,3'-phosphate-1'-phosphate synthase domain uses only 1L-myo-inositol 1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-L-myo-inositol and CDP-D-myo-inositol, are recognized as alcohol donors Pyrococcus furiosus CMP + myo-L-inositol 1,1'-phosphoglycerol
-
 ?
2.7.8.34 CDP-glycerol + 1D-myo-inositol 3-phosphate bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase. The cytidylyltransferase is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The di-myo-inositol-1,3'-phosphate-1'-phosphate synthase domain uses only 1L-myo-inositol 1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-L-myo-inositol and CDP-D-myo-inositol, are recognized as alcohol donors Thermococcus kodakarensis CMP + myo-L-inositol 1,1'-phosphoglycerol
-
 ?
2.7.8.34 CDP-glycerol + 1D-myo-inositol 3-phosphate bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase. The cytidylyltransferase is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The di-myo-inositol-1,3'-phosphate-1'-phosphate synthase domain uses only 1L-myo-inositol 1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-L-myo-inositol and CDP-D-myo-inositol, are recognized as alcohol donors Aquifex aeolicus CMP + myo-L-inositol 1,1'-phosphoglycerol
-
 ?
2.7.8.34 CDP-glycerol + 1L-myo-inositol 1-phosphate bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase. The cytidylyltransferase is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The di-myo-inositol-1,3'-phosphate-1'-phosphate synthase domain uses only 1L-myo-inositol 1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-L-myo-inositol and CDP-D-myo-inositol, are recognized as alcohol donors Archaeoglobus fulgidus CMP + 1L-(1X-glyceryl)-myo-inositol phosphate 3-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.74 CTP:inositol-1-phosphate cytidylyltransferase bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS) Archaeoglobus fulgidus
2.7.7.74 CTP:inositol-1-phosphate cytidylyltransferase bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS) Pyrococcus furiosus
2.7.7.74 CTP:inositol-1-phosphate cytidylyltransferase bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS) Thermococcus kodakarensis
2.7.7.74 CTP:inositol-1-phosphate cytidylyltransferase bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS) Aquifex aeolicus
2.7.7.74 CTP:inositol-1-phosphate cytidylyltransferase no CDP-inositol:inositol-1-phosphate transferase activity detected Rubrobacter xylanophilus
2.7.7.74 IPCT bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS) Archaeoglobus fulgidus
2.7.7.74 IPCT bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS) Pyrococcus furiosus
2.7.7.74 IPCT bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS) Thermococcus kodakarensis
2.7.7.74 IPCT bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS) Aquifex aeolicus
2.7.8.34 CDP-inositol:inositol-1-phosphate transferase bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS) Archaeoglobus fulgidus
2.7.8.34 CDP-inositol:inositol-1-phosphate transferase bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS) Pyrococcus furiosus
2.7.8.34 CDP-inositol:inositol-1-phosphate transferase bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS) Thermococcus kodakarensis
2.7.8.34 CDP-inositol:inositol-1-phosphate transferase bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS) Aquifex aeolicus
2.7.8.34 DIPPS bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS) Archaeoglobus fulgidus
2.7.8.34 DIPPS bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS) Pyrococcus furiosus
2.7.8.34 DIPPS bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS) Thermococcus kodakarensis
2.7.8.34 DIPPS bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS) Aquifex aeolicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.7.74 80
-
 assay at Archaeoglobus fulgidus
2.7.7.74 80
-
 assay at Pyrococcus furiosus
2.7.7.74 80
-
 assay at Thermococcus kodakarensis
2.7.7.74 80
-
 assay at Aquifex aeolicus
2.7.7.74 80
-
 assay at Rubrobacter xylanophilus
2.7.8.34 80
-
 assay at Archaeoglobus fulgidus
2.7.8.34 80
-
 assay at Pyrococcus furiosus
2.7.8.34 80
-
 assay at Thermococcus kodakarensis
2.7.8.34 80
-
 assay at Aquifex aeolicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.7.74 7.6
-
 assay at Archaeoglobus fulgidus
2.7.7.74 7.6
-
 assay at Pyrococcus furiosus
2.7.7.74 7.6
-
 assay at Thermococcus kodakarensis
2.7.7.74 7.6
-
 assay at Aquifex aeolicus
2.7.7.74 7.6
-
 assay at Rubrobacter xylanophilus
2.7.8.34 7.6
-
 assay at Archaeoglobus fulgidus
2.7.8.34 7.6
-
 assay at Pyrococcus furiosus
2.7.8.34 7.6
-
 assay at Thermococcus kodakarensis
2.7.8.34 7.6
-
 assay at Aquifex aeolicus