Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Dohi, S.; Terasaki, M.; Makino, M.
    Acetylcholinesterase inhibitory activity and chemical composition of commercial essential oils (2009), J. Agric. Food Chem., 57, 4313-4318.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.7 1,8-cineole IC50 is 0.015 mg/ml Electrophorus electricus
3.1.1.7 alpha-pinene IC50 is 0.022 mg/ml Electrophorus electricus
3.1.1.7 alpha-terpineol IC50 is 1.3 mg/ml Electrophorus electricus
3.1.1.7 eugenol IC50 is 0.48 mg/ml Electrophorus electricus
3.1.1.7 additional information commercially available essential oils extracted from Artemisia dracunculus L., Inula graveolens L., Lavandula officinalis Chaix, and Ocimum sanctum L. show inhibitory activity on the enzyme, with highest inhibitory activity of Artemisia dracunculus oil with an IC50 of 0.058 mg/ml, overview Electrophorus electricus
3.1.1.7 terpinen-4-ol IC50 is 3.2 mg/ml Electrophorus electricus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.7 acetylcholine + H2O Electrophorus electricus
-
 acetate + choline
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.7 Electrophorus electricus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.7 acetylcholine + H2O
-
 Electrophorus electricus acetate + choline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.7 AChE
-
 Electrophorus electricus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.7 37
-
 assay at Electrophorus electricus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.7 additional information
-
 pH not specified in the publication Electrophorus electricus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.1.7 additional information
-
 IC50s: for 1,8-cineole 0.015 mg/ml, for alpha-pinene 0.022 mg/ml, for eugenol 0.48 mg/ml, for alpha-terpineol 1.3 mg/ml, for terpinen-4-ol 3.2 mg/ml, at 37°C, pH not specified in the publication Electrophorus electricus additional information