BRENDA - Enzyme Database

Activation of native TRPC3 cation channels by phospholipase D

Glitsch, M.D.; FASEB J. 24, 318-325 (2010)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
3.1.4.4
ARF protein
small G proteins of the Rho and Arf families activate phospholipase D1
Rattus norvegicus
3.1.4.4
phosphatidylinositol-4,5-bisphosphate
an essential cofactor for phospholipase D1 activity
Rattus norvegicus
3.1.4.4
Rho protein
small G proteins of the Rho and Arf families activate phospholipase D1. Small GTPases might be involved in the activation mechanism of TRPC3 in rat cerebellar Purkinje cells. Rho GTPases can activate phospholipase D1 through two mechanisms: direct binding to phospholipase D1 or activation of phosphatidylinositol-4,5-kinase, which triggers phosphatidylinositol-4,5-bisphosphate production, an essential cofactor for phospholipase D1 activity
Rattus norvegicus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.4.4
1-butanol
does not causes direct inhibition of TRPC3 channels, but causes blocking of phospholipase D which interferes with retrograde signaling, overview. Neither voltage-gated Ca2+-channels nor Ca2+-activated Cl channels are affected by 1-butanol
Rattus norvegicus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.4.4
additional information
ativation of mGluR1 leads to phospholipase D1 translocation in granule cells, activation of mGluR1 triggers migration and thus activation of PLD1 in a cell-specific manner in the cerebellum
Rattus norvegicus
-
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
3.1.4.4
additional information
Rattus norvegicus
phospholipase D activates native TRPC3 cation channels after stimulation of G-protein-coupled type I glutamate receptors in the cerebellum. Small GTPases might be involved in the activation mechanism of TRPC3 in rat cerebellar Purkinje cells, overview
?
-
-
-
Organism
EC Number
Organism
UniProt
Commentary
Textmining
3.1.4.4
Rattus norvegicus
-
isozyme PLD1
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.4.4
brain
-
Rattus norvegicus
-
3.1.4.4
cerebellar Purkinje cell
-
Rattus norvegicus
-
3.1.4.4
cerebellum
-
Rattus norvegicus
-
3.1.4.4
granule cell
-
Rattus norvegicus
-
3.1.4.4
neuron
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
3.1.4.4
additional information
phospholipase D activates native TRPC3 cation channels after stimulation of G-protein-coupled type I glutamate receptors in the cerebellum. Small GTPases might be involved in the activation mechanism of TRPC3 in rat cerebellar Purkinje cells, overview
708464
Rattus norvegicus
?
-
-
-
-
Synonyms
EC Number
Synonyms
Commentary
Organism
3.1.4.4
phospholipase D1
-
Rattus norvegicus
3.1.4.4
PLD-1
-
Rattus norvegicus
3.1.4.4
PLD1
-
Rattus norvegicus
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
3.1.4.4
ARF protein
small G proteins of the Rho and Arf families activate phospholipase D1
Rattus norvegicus
3.1.4.4
phosphatidylinositol-4,5-bisphosphate
an essential cofactor for phospholipase D1 activity
Rattus norvegicus
3.1.4.4
Rho protein
small G proteins of the Rho and Arf families activate phospholipase D1. Small GTPases might be involved in the activation mechanism of TRPC3 in rat cerebellar Purkinje cells. Rho GTPases can activate phospholipase D1 through two mechanisms: direct binding to phospholipase D1 or activation of phosphatidylinositol-4,5-kinase, which triggers phosphatidylinositol-4,5-bisphosphate production, an essential cofactor for phospholipase D1 activity
Rattus norvegicus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.4.4
1-butanol
does not causes direct inhibition of TRPC3 channels, but causes blocking of phospholipase D which interferes with retrograde signaling, overview. Neither voltage-gated Ca2+-channels nor Ca2+-activated Cl channels are affected by 1-butanol
Rattus norvegicus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.4.4
additional information
ativation of mGluR1 leads to phospholipase D1 translocation in granule cells, activation of mGluR1 triggers migration and thus activation of PLD1 in a cell-specific manner in the cerebellum
Rattus norvegicus
-
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
3.1.4.4
additional information
Rattus norvegicus
phospholipase D activates native TRPC3 cation channels after stimulation of G-protein-coupled type I glutamate receptors in the cerebellum. Small GTPases might be involved in the activation mechanism of TRPC3 in rat cerebellar Purkinje cells, overview
?
-
-
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.4.4
brain
-
Rattus norvegicus
-
3.1.4.4
cerebellar Purkinje cell
-
Rattus norvegicus
-
3.1.4.4
cerebellum
-
Rattus norvegicus
-
3.1.4.4
granule cell
-
Rattus norvegicus
-
3.1.4.4
neuron
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
3.1.4.4
additional information
phospholipase D activates native TRPC3 cation channels after stimulation of G-protein-coupled type I glutamate receptors in the cerebellum. Small GTPases might be involved in the activation mechanism of TRPC3 in rat cerebellar Purkinje cells, overview
708464
Rattus norvegicus
?
-
-
-
-
General Information
EC Number
General Information
Commentary
Organism
3.1.4.4
physiological function
key role for phospholipase D in the generation of the slow excitatory postsynaptic current in cerebellar Purkinje cells
Rattus norvegicus
General Information (protein specific)
EC Number
General Information
Commentary
Organism
3.1.4.4
physiological function
key role for phospholipase D in the generation of the slow excitatory postsynaptic current in cerebellar Purkinje cells
Rattus norvegicus