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Literature summary extracted from

  • Revermann, M.
    Pharmacological inhibition of the soluble epoxide hydrolase-from mouse to man (2010), Curr. Opin. Pharmacol., 10, 173-178.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.3.2.10 additional information sEH inhibitors are 1,3-disubstituted ureas, amides and carbamates that have IC50-values in the low nanomolar range. They only block the hydrolase activity of the enzyme without affecting the phosphatase domain Mammalia

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.3.2.10 soluble
-
 Mammalia
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.3.2.10 62000
-
 2 * 62000 Mammalia

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.10 Mammalia
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.3.2.10 heart
-
 Mammalia
-
3.3.2.10 kidney
-
 Mammalia
-
3.3.2.10 additional information sEH is ubiquituously expressed Mammalia
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.3.2.10 additional information the enzyme possesses an epoxide hydrolyzing as well as a lipid phosphatase activity. Favored sEH substrates are trans-substituted over cis-substituted epoxides Mammalia ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.3.2.10 homodimer 2 * 62000 Mammalia

Synonyms

EC Number Synonyms Comment Organism
3.3.2.10 SEH
-
 Mammalia

General Information

EC Number General Information Comment Organism
3.3.2.10 additional information sEh inhibition reduces inflammation. In several mouse models, sEH inhibition reduces atherosclerosis and aortic aneurysm formation. The anti-proliferative effect of urea-based sEH inhibitors is probably caused by PPARa activation and consecutive inhibition of cyclin D1 expression. And sEH inhibition affects renal fucntions, overview Mammalia
3.3.2.10 physiological function sEH is not essentially involved in the metabolization and clearance of carcinogenic xenobiotics. But sEH is involved in inflammation Mammalia