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Literature summary extracted from
- Phospholipase D mechanism using Streptomyces PLD (2009), Biochim. Biophys. Acta, 1791, 962-969.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.1.4.4 | synthesis | creation of a high performance PLD with superior transphosphatidylation activity and low hydrolysis activity can be very useful for the synthesis of phospholipids used in pharmaceuticals, foods, cosmetics, and other industries | Streptomyces cinnamoneus |
| 3.1.4.4 | synthesis | creation of a high performance PLD with superior transphosphatidylation activity and low hydrolysis activity can be very useful for the synthesis of phospholipids used in pharmaceuticals, foods, cosmetics, and other industries | Streptomyces antibioticus |
| 3.1.4.4 | synthesis | creation of a high performance PLD with superior transphosphatidylation activity and low hydrolysis activity can be very useful for the synthesis of phospholipids used in pharmaceuticals, foods, cosmetics, and other industries | Streptomyces halstedii |
| 3.1.4.4 | synthesis | creation of a high performance PLD with superior transphosphatidylation activity and low hydrolysis activity can be very useful for the synthesis of phospholipids used in pharmaceuticals, foods, cosmetics, and other industries | Streptomyces septatus |
| 3.1.4.4 | synthesis | creation of a high performance PLD with superior transphosphatidylation activity and low hydrolysis activity can be very useful for the synthesis of phospholipids used in pharmaceuticals, foods, cosmetics, and other industries | Streptomyces sp. |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.1.4.4 | PLD DNA and amino acid sequence determination, comparison, and analysis | Streptomyces cinnamoneus |
| 3.1.4.4 | PLD DNA and amino acid sequence determination, comparison, and analysis | Streptomyces antibioticus |
| 3.1.4.4 | PLD DNA and amino acid sequence determination, comparison, and analysis | Streptomyces halstedii |
| 3.1.4.4 | PLD DNA and amino acid sequence determination, comparison, and analysis | Streptomyces septatus |
| 3.1.4.4 | PLD DNA and amino acid sequence determination, comparison, and analysis | Streptomyces sp. |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.4 | phosphatidylcholine + H2O | Streptomyces cinnamoneus | - |
choline + phosphatidic acid | - |
? |  |
| 3.1.4.4 | phosphatidylcholine + H2O | Streptomyces antibioticus | - |
choline + phosphatidic acid | - |
? | |
| 3.1.4.4 | phosphatidylcholine + H2O | Streptomyces halstedii | - |
choline + phosphatidic acid | - |
? | |
| 3.1.4.4 | phosphatidylcholine + H2O | Streptomyces septatus | - |
choline + phosphatidic acid | - |
? | |
| 3.1.4.4 | phosphatidylcholine + H2O | Streptomyces sp. | - |
choline + phosphatidic acid | - |
? | |
| 3.1.4.4 | phosphatidylglycerol + H2O | Streptomyces cinnamoneus | - |
glycerol + phosphatidic acid | - |
? | |
| 3.1.4.4 | phosphatidylglycerol + H2O | Streptomyces antibioticus | - |
glycerol + phosphatidic acid | - |
? | |
| 3.1.4.4 | phosphatidylglycerol + H2O | Streptomyces halstedii | - |
glycerol + phosphatidic acid | - |
? | |
| 3.1.4.4 | phosphatidylglycerol + H2O | Streptomyces septatus | - |
glycerol + phosphatidic acid | - |
? | |
| 3.1.4.4 | phosphatidylglycerol + H2O | Streptomyces sp. | - |
glycerol + phosphatidic acid | - |
? | |
| 3.1.4.4 | phosphatidylserine + H2O | Streptomyces cinnamoneus | - |
serine + phosphatidic acid | - |
? | |
| 3.1.4.4 | phosphatidylserine + H2O | Streptomyces antibioticus | - |
serine + phosphatidic acid | - |
? | |
| 3.1.4.4 | phosphatidylserine + H2O | Streptomyces halstedii | - |
serine + phosphatidic acid | - |
? | |
| 3.1.4.4 | phosphatidylserine + H2O | Streptomyces septatus | - |
serine + phosphatidic acid | - |
? | |
| 3.1.4.4 | phosphatidylserine + H2O | Streptomyces sp. | - |
serine + phosphatidic acid | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.4.4 | Streptomyces antibioticus | - |
- |
- |
| 3.1.4.4 | Streptomyces cinnamoneus | - |
- |
- |
| 3.1.4.4 | Streptomyces halstedii | - |
- |
- |
| 3.1.4.4 | Streptomyces septatus | - |
- |
- |
| 3.1.4.4 | Streptomyces sp. | P84147 | PMF strain | - |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 3.1.4.4 | a phosphatidylcholine + H2O = choline + a phosphatidate | catalytic mechanism, PLD uses a ping-pong type of reaction through the formation of a covalent phosphatidyl-enzyme intermediate, structure-function relationship, and substrate recognition and specificity, overview | Streptomyces cinnamoneus | |
| 3.1.4.4 | a phosphatidylcholine + H2O = choline + a phosphatidate | catalytic mechanism, PLD uses a ping-pong type of reaction through the formation of a covalent phosphatidyl-enzyme intermediate, structure-function relationship, and substrate recognition and specificity, overview | Streptomyces antibioticus | |
| 3.1.4.4 | a phosphatidylcholine + H2O = choline + a phosphatidate | catalytic mechanism, PLD uses a ping-pong type of reaction through the formation of a covalent phosphatidyl-enzyme intermediate, structure-function relationship, and substrate recognition and specificity, overview | Streptomyces halstedii | |
| 3.1.4.4 | a phosphatidylcholine + H2O = choline + a phosphatidate | catalytic mechanism, PLD uses a ping-pong type of reaction through the formation of a covalent phosphatidyl-enzyme intermediate, structure-function relationship, and substrate recognition and specificity, overview | Streptomyces septatus | |
| 3.1.4.4 | a phosphatidylcholine + H2O = choline + a phosphatidate | catalytic mechanism, PLD uses a ping-pong type of reaction through the formation of a covalent phosphatidyl-enzyme intermediate, structure-function relationship, and substrate recognition and specificity, overview | Streptomyces sp. |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.4 | additional information | PLD performs two different reactions: a hydrolytic reaction and a transphosphatidylation reaction, the latter with a primary alcohol, both pathway share a common intermediate, mechanism, overview | Streptomyces cinnamoneus | ? | - |
? | |
| 3.1.4.4 | additional information | PLD performs two different reactions: a hydrolytic reaction and a transphosphatidylation reaction, the latter with a primary alcohol, both pathway share a common intermediate, mechanism, overview | Streptomyces antibioticus | ? | - |
? | |
| 3.1.4.4 | additional information | PLD performs two different reactions: a hydrolytic reaction and a transphosphatidylation reaction, the latter with a primary alcohol, both pathway share a common intermediate, mechanism, overview | Streptomyces halstedii | ? | - |
? | |
| 3.1.4.4 | additional information | PLD performs two different reactions: a hydrolytic reaction and a transphosphatidylation reaction, the latter with a primary alcohol, both pathway share a common intermediate, mechanism, overview | Streptomyces septatus | ? | - |
? | |
| 3.1.4.4 | additional information | PLD performs two different reactions: a hydrolytic reaction and a transphosphatidylation reaction, the latter with a primary alcohol, both pathway share a common intermediate, mechanism, overview | Streptomyces sp. | ? | - |
? | |
| 3.1.4.4 | phosphatidylcholine + H2O | - |
Streptomyces cinnamoneus | choline + phosphatidic acid | - |
? | |
| 3.1.4.4 | phosphatidylcholine + H2O | - |
Streptomyces antibioticus | choline + phosphatidic acid | - |
? | |
| 3.1.4.4 | phosphatidylcholine + H2O | - |
Streptomyces halstedii | choline + phosphatidic acid | - |
? | |
| 3.1.4.4 | phosphatidylcholine + H2O | - |
Streptomyces septatus | choline + phosphatidic acid | - |
? | |
| 3.1.4.4 | phosphatidylcholine + H2O | - |
Streptomyces sp. | choline + phosphatidic acid | - |
? | |
| 3.1.4.4 | phosphatidylglycerol + H2O | - |
Streptomyces cinnamoneus | glycerol + phosphatidic acid | - |
? | |
| 3.1.4.4 | phosphatidylglycerol + H2O | - |
Streptomyces antibioticus | glycerol + phosphatidic acid | - |
? | |
| 3.1.4.4 | phosphatidylglycerol + H2O | - |
Streptomyces halstedii | glycerol + phosphatidic acid | - |
? | |
| 3.1.4.4 | phosphatidylglycerol + H2O | - |
Streptomyces septatus | glycerol + phosphatidic acid | - |
? | |
| 3.1.4.4 | phosphatidylglycerol + H2O | - |
Streptomyces sp. | glycerol + phosphatidic acid | - |
? | |
| 3.1.4.4 | phosphatidylserine + H2O | - |
Streptomyces cinnamoneus | serine + phosphatidic acid | - |
? | |
| 3.1.4.4 | phosphatidylserine + H2O | - |
Streptomyces antibioticus | serine + phosphatidic acid | - |
? | |
| 3.1.4.4 | phosphatidylserine + H2O | - |
Streptomyces halstedii | serine + phosphatidic acid | - |
? | |
| 3.1.4.4 | phosphatidylserine + H2O | - |
Streptomyces septatus | serine + phosphatidic acid | - |
? | |
| 3.1.4.4 | phosphatidylserine + H2O | - |
Streptomyces sp. | serine + phosphatidic acid | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.4.4 | More | the enzyme belongs to the PLD superfamily containing two HKD motifs | Streptomyces cinnamoneus |
| 3.1.4.4 | More | the enzyme belongs to the PLD superfamily containing two HKD motifs | Streptomyces antibioticus |
| 3.1.4.4 | More | the enzyme belongs to the PLD superfamily containing two HKD motifs | Streptomyces halstedii |
| 3.1.4.4 | More | the enzyme belongs to the PLD superfamily containing two HKD motifs | Streptomyces septatus |
| 3.1.4.4 | More | the enzyme belongs to the PLD superfamily containing two HKD motifs | Streptomyces sp. |
| 3.1.4.4 | PLD | - |
Streptomyces cinnamoneus |
| 3.1.4.4 | PLD | - |
Streptomyces antibioticus |
| 3.1.4.4 | PLD | - |
Streptomyces halstedii |
| 3.1.4.4 | PLD | - |
Streptomyces septatus |
| 3.1.4.4 | PLD | - |
Streptomyces sp. |
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