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Literature summary extracted from

  • Li, J.H.; DAlessio, A.; Pober, J.S.
    Lipopolysaccharide can trigger a cathepsin B-dependent programmed death response in human endothelial cells (2009), Am. J. Pathol., 175, 1124-1135.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.22.1 lipopolysaccharide activates a Cat-B-dependent programmed death response in endothelial cells that is independent of both myeloid differentiation factor 88 and Toll-like receptor-associated interferon-inducing factor, is blocked by both Fas-associated death domain protein and phosphatidylinositol 3 kinase. Activates both caspase- and Cat B-dependent death pathways in presence of phosphatidylinositol 3 kinase inhibitor LY294002 or the inflammatory cytokine interferon-gamma Homo sapiens
3.4.22.1 additional information knockdown of cellular FLICE inhibitory protein potentiates the caspase-dependent pathway but does not activate the Cat B-dependent death response. Also knockdown of either myeloid differentiation factor 88 or Toll-like receptor-associated interferon-inducing factor expression does not affect the LPS-triggered Cat B death response in Fas-associated death domain protein-deficient human umbilical vein endothelial cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.1 CA-074-Me Cat B-selective inhibitor Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.1 endothelial cell human umbilical vein endothelial cells, HUVECs Homo sapiens
-
3.4.22.1 umbilical vein human umbilical vein endothelial cells, HUVECs Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
3.4.22.1 cat B
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.22.1 additional information based on the use of proteinase inhibitors, cell death changes from being principally caspase-dependent to being principally cathepsin B-dependent, overview Homo sapiens