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Literature summary extracted from

  • Basak, A.; Shervani, N.; Kolajova, M.; Cherla, S.; Basak, S.
    Novel reactive site loop derived mini-serpin inhibitors of recombinant proprotein convertase 4 (2009), Adv. Exp. Med. Biol., 611, 105-106.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.B24 recombinant expression using the Leishmania tarentolae expression system Mammalia

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.B24 CRES peptides development of PC4 inhibitors based onthe CRES reactive site loop, miniserpin inhibitors, sequences, overview Mammalia

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.B24 acrosome
-
 Mammalia
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.21.B24 Ca2+ dependent on Mammalia

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.B24 additional information Mammalia PC4 substrates are growth factors proIGF-1 and proIGF-2, hormonal polypeptides, proPACAP, and surface proteins of the ADAM family, e.g. ADAM1 or fertilin alpha, ADAM2 or fertilin beta, ADAM3 or cyritestin, and ADAM5 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.B24 Mammalia
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.B24 macrophage ovarian Mammalia
-
3.4.21.B24 placenta
-
 Mammalia
-
3.4.21.B24 sperm
-
 Mammalia
-
3.4.21.B24 spermatocyte
-
 Mammalia
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.B24 additional information PC4 substrates are growth factors proIGF-1 and proIGF-2, hormonal polypeptides, proPACAP, and surface proteins of the ADAM family, e.g. ADAM1 or fertilin alpha, ADAM2 or fertilin beta, ADAM3 or cyritestin, and ADAM5 Mammalia ?
-
 ?
3.4.21.B24 additional information PC4 cleaves peptide bonds in the sequence R/K/H-X-X/R/K/-R, with X being any amino acid except cysteine, a preferred motif is KXKR Mammalia ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.B24 PC4
-
 Mammalia

General Information

EC Number General Information Comment Organism
3.4.21.B24 physiological function PC4 activates everal protein precursors in the secretory pathway of mammalian reproduction system with a vital role in fertilization and sperm maturation Mammalia