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Literature summary extracted from
- Inhibition of MMP-3 activity and invasion of the MDA-MB-231 human invasive breast carcinoma cell line by bioflavonoids (2009), Acta Pharmacol. Sin., 30, 1169-1176.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.17 | daidzein | - |
Homo sapiens |  |
| 3.4.24.17 | genistein | - |
Homo sapiens | |
| 3.4.24.17 | genistin | - |
Homo sapiens | |
| 3.4.24.17 | kaempferol | - |
Homo sapiens | |
| 3.4.24.17 | additional information | the flavonols quercetin and kaempferol have higher anti-invasion potency and higher MMP-3 inhibitory activity than isoflavones genistein, genistin and daidzein, but neither flavonols nor isoflavones have any effect on MMP-3 secretion | Homo sapiens | |
| 3.4.24.17 | quercetin | - |
Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.24.17 | extracellular | MMP-3 is secreted | Homo sapiens | - |
- |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.17 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.24.17 | MDA-MB-231 cell | a human invasive breast carcinoma cell line | Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.17 | casein + H2O | casein zymography assay | Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.24.17 | Matrix metalloproteinase 3 | - |
Homo sapiens |
| 3.4.24.17 | MMP-3 | - |
Homo sapiens |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.17 | 37 | - |
assay at | Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.17 | 7.4 | - |
assay at | Homo sapiens |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.4.24.17 | malfunction | MMP-3 is involved in breast cancer cell invasiveness | Homo sapiens |
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