Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Hiskett, E.K.; Suwitheechon, O.U.; Lindbloom-Hawley, S.; Boyle, D.L.; Schermerhorn, T.
    Lack of glucokinase regulatory protein expression may contribute to low glucokinase activity in feline liver (2009), Vet. Res. Commun., 33, 227-240.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.1 glucokinase regulatory protein binds glucokinase in the nucleus and inhibits its activity Canis lupus familiaris
2.7.1.1 glucokinase regulatory protein binds glucokinase in the nucleus and inhibits its activity Felis catus
2.7.1.1 glucokinase regulatory protein binds glucokinase in the nucleus and inhibits its activity Rattus norvegicus
2.7.1.1 additional information not inhibited by D-glucose-6-phosphate Canis lupus familiaris
2.7.1.1 additional information not inhibited by D-glucose-6-phosphate Felis catus
2.7.1.1 additional information not inhibited by D-glucose-6-phosphate Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.1 cytosol glucokinase becomes active when it is released from glucokinase regulatory protein and translocates to the cytosol Rattus norvegicus 5829
-
2.7.1.1 cytosol glucokinase becomes active when it is released from glucokinase regulatory protein and translocates to the cytosol Canis lupus familiaris 5829
-
2.7.1.1 cytosol glucokinase becomes active when it is released from glucokinase regulatory protein and translocates to the cytosol Felis catus 5829
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.1 Canis lupus familiaris
-
-
-
2.7.1.1 Felis catus
-
-
-
2.7.1.1 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.1 liver
-
 Rattus norvegicus
-
2.7.1.1 liver
-
 Canis lupus familiaris
-
2.7.1.1 liver
-
 Felis catus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.1 ATP + D-glucose
-
 Rattus norvegicus ADP + D-glucose 6-phosphate
-
 ?
2.7.1.1 ATP + D-glucose
-
 Canis lupus familiaris ADP + D-glucose 6-phosphate
-
 ?
2.7.1.1 ATP + D-glucose
-
 Felis catus ADP + D-glucose 6-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.1 glucokinase
-
 Rattus norvegicus
2.7.1.1 glucokinase
-
 Canis lupus familiaris
2.7.1.1 glucokinase
-
 Felis catus
2.7.1.1 HK4
-
 Rattus norvegicus
2.7.1.1 HK4
-
 Canis lupus familiaris
2.7.1.1 HK4
-
 Felis catus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.1 ATP
-
 Rattus norvegicus
2.7.1.1 ATP
-
 Canis lupus familiaris
2.7.1.1 ATP
-
 Felis catus

General Information

EC Number General Information Comment Organism
2.7.1.1 physiological function glucokinase acts as a hepatic glucose sensor that permits hepatic metabolism to respond appropriately to changes in plasma glucose concentrations Rattus norvegicus
2.7.1.1 physiological function glucokinase acts as a hepatic glucose sensor that permits hepatic metabolism to respond appropriately to changes in plasma glucose concentrations Canis lupus familiaris
2.7.1.1 physiological function glucokinase acts as a hepatic glucose sensor that permits hepatic metabolism to respond appropriately to changes in plasma glucose concentrations Felis catus