Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Kwapisz, M.; Beckouet, F.; Thuriaux, P.
    Early evolution of eukaryotic DNA-dependent RNA polymerases (2008), Trends Genet., 24, 211-215.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.7.6 structure-based analysis of the evolution of archaeal and eukaryotic DNA-dependent RNA polymerases, overview Cenarchaeum symbiosum
2.7.7.6 structure-based analysis of the evolution of archaeal and eukaryotic DNA-dependent RNA polymerases, overview Nitrosopumilus maritimus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.7.6 additional information mutagenesis by amino-acid replacements altering the RNA polymerase II Switch 1 loop domain, such as rpb1-L1397S. rpb1-L1397S enhances RNA polymerase II occupancy downstream of the URA2 initiator Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.6 additional information a relatively short DNA region, lost in up2DELTA mutant and located immediately upstream of the URA2 initiator, impairs URA2 transcription by preventing RNA polymerase II from progressing towards the URA2open reading frame Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.6 nucleus distribution of TFIIB, TFIIH and RNA polymerase II at the URA2 locus, RNA polymerase II occupancy is increased on the URA2 open reading frame, overview Saccharomyces cerevisiae 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.6 additional information Saccharomyces cerevisiae the Switch 1 loop of RNA polymerase II, located at the downstream end of the transcription bubble, may operate as a specific sensor of the nucleoside triphosphates available for transcription. Regulatory effects of RNA polymerase II on URA2 gene, encoding the rate-limiting enzyme of UTP biosynthesis after activation by UTP shortage, RNA polymerase II occupancy is increased on the URA2 open reading frame, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.6 Caldivirga maquilingensis
-
-
-
2.7.7.6 Cenarchaeum symbiosum
-
-
-
2.7.7.6 Emiliania huxleyi
-
-
-
2.7.7.6 Escherichia coli
-
-
-
2.7.7.6 Methanocaldococcus jannaschii
-
-
-
2.7.7.6 Nanoarchaeum equitans
-
-
-
2.7.7.6 Nitrosopumilus maritimus
-
-
-
2.7.7.6 Pyrococcus furiosus
-
-
-
2.7.7.6 Saccharolobus solfataricus
-
-
-
2.7.7.6 Saccharomyces cerevisiae
-
-
-
2.7.7.6 Sulfolobus acidocaldarius
-
-
-
2.7.7.6 Thermofilum pendens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.6 additional information the Switch 1 loop of RNA polymerase II, located at the downstream end of the transcription bubble, may operate as a specific sensor of the nucleoside triphosphates available for transcription. Regulatory effects of RNA polymerase II on URA2 gene, encoding the rate-limiting enzyme of UTP biosynthesis after activation by UTP shortage, RNA polymerase II occupancy is increased on the URA2 open reading frame, overview Saccharomyces cerevisiae ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.7.6 More secondary structure and organization of multi-subunit DNA-dependent RNA polymerases, overview. The Rpb8/G RNA polymerase subunit is restricted to eukaryotes and Crenarchaea Escherichia coli
2.7.7.6 More secondary structure and organization of multi-subunit DNA-dependent RNA polymerases, overview. The Rpb8/G RNA polymerase subunit is restricted to eukaryotes and Crenarchaea Saccharomyces cerevisiae
2.7.7.6 More secondary structure and organization of multi-subunit DNA-dependent RNA polymerases, overview. The Rpb8/G RNA polymerase subunit is restricted to eukaryotes and Crenarchaea Pyrococcus furiosus
2.7.7.6 More secondary structure and organization of multi-subunit DNA-dependent RNA polymerases, overview. The Rpb8/G RNA polymerase subunit is restricted to eukaryotes and Crenarchaea Sulfolobus acidocaldarius
2.7.7.6 More secondary structure and organization of multi-subunit DNA-dependent RNA polymerases, overview. The Rpb8/G RNA polymerase subunit is restricted to eukaryotes and Crenarchaea Emiliania huxleyi
2.7.7.6 More secondary structure and organization of multi-subunit DNA-dependent RNA polymerases, overview. The Rpb8/G RNA polymerase subunit is restricted to eukaryotes and Crenarchaea Cenarchaeum symbiosum
2.7.7.6 More secondary structure and organization of multi-subunit DNA-dependent RNA polymerases, overview. The Rpb8/G RNA polymerase subunit is restricted to eukaryotes and Crenarchaea Caldivirga maquilingensis
2.7.7.6 More secondary structure and organization of multi-subunit DNA-dependent RNA polymerases, overview. The Rpb8/G RNA polymerase subunit is restricted to eukaryotes and Crenarchaea Thermofilum pendens
2.7.7.6 More secondary structure and organization of multi-subunit DNA-dependent RNA polymerases, overview. The Rpb8/G RNA polymerase subunit is restricted to eukaryotes and Crenarchaea Nitrosopumilus maritimus
2.7.7.6 More secondary structure and organization of multi-subunit DNA-dependent RNA polymerases, overview. The Rpb8/G RNA polymerase subunit is restricted to eukaryotes and Crenarchaea. The enzyme lacks the G and M polypeptides Methanocaldococcus jannaschii
2.7.7.6 More secondary structure and organization of multi-subunit DNA-dependent RNA polymerases, overview. The Rpb8/G RNA polymerase subunit is restricted to eukaryotes and Crenarchaea. The enzyme lacks the G subunit Saccharolobus solfataricus
2.7.7.6 More secondary structure and organization of multi-subunit DNA-dependent RNA polymerases, overview. The Rpb8/G RNA polymerase subunit is restricted to eukaryotes and Crenarchaea. The enzyme lacks the G subunit Nanoarchaeum equitans

Synonyms

EC Number Synonyms Comment Organism
2.7.7.6 DNA-dependent RNA polymerase
-
 Escherichia coli
2.7.7.6 DNA-dependent RNA polymerase
-
 Saccharomyces cerevisiae
2.7.7.6 DNA-dependent RNA polymerase
-
 Pyrococcus furiosus
2.7.7.6 DNA-dependent RNA polymerase
-
 Sulfolobus acidocaldarius
2.7.7.6 DNA-dependent RNA polymerase
-
 Saccharolobus solfataricus
2.7.7.6 DNA-dependent RNA polymerase
-
 Methanocaldococcus jannaschii
2.7.7.6 DNA-dependent RNA polymerase
-
 Emiliania huxleyi
2.7.7.6 DNA-dependent RNA polymerase
-
 Cenarchaeum symbiosum
2.7.7.6 DNA-dependent RNA polymerase
-
 Nanoarchaeum equitans
2.7.7.6 DNA-dependent RNA polymerase
-
 Caldivirga maquilingensis
2.7.7.6 DNA-dependent RNA polymerase
-
 Thermofilum pendens
2.7.7.6 DNA-dependent RNA polymerase
-
 Nitrosopumilus maritimus
2.7.7.6 Pol I
-
 Escherichia coli
2.7.7.6 Pol I
-
 Saccharomyces cerevisiae
2.7.7.6 Pol I
-
 Pyrococcus furiosus
2.7.7.6 Pol I
-
 Sulfolobus acidocaldarius
2.7.7.6 Pol I
-
 Saccharolobus solfataricus
2.7.7.6 Pol I
-
 Methanocaldococcus jannaschii
2.7.7.6 Pol I
-
 Emiliania huxleyi
2.7.7.6 Pol I
-
 Cenarchaeum symbiosum
2.7.7.6 Pol I
-
 Nanoarchaeum equitans
2.7.7.6 Pol I
-
 Caldivirga maquilingensis
2.7.7.6 Pol I
-
 Thermofilum pendens
2.7.7.6 Pol I
-
 Nitrosopumilus maritimus
2.7.7.6 Pol II
-
 Escherichia coli
2.7.7.6 Pol II
-
 Saccharomyces cerevisiae
2.7.7.6 Pol II
-
 Pyrococcus furiosus
2.7.7.6 Pol II
-
 Sulfolobus acidocaldarius
2.7.7.6 Pol II
-
 Saccharolobus solfataricus
2.7.7.6 Pol II
-
 Methanocaldococcus jannaschii
2.7.7.6 Pol II
-
 Emiliania huxleyi
2.7.7.6 Pol II
-
 Cenarchaeum symbiosum
2.7.7.6 Pol II
-
 Nanoarchaeum equitans
2.7.7.6 Pol II
-
 Caldivirga maquilingensis
2.7.7.6 Pol II
-
 Thermofilum pendens
2.7.7.6 Pol II
-
 Nitrosopumilus maritimus
2.7.7.6 pol III
-
 Escherichia coli
2.7.7.6 pol III
-
 Saccharomyces cerevisiae
2.7.7.6 pol III
-
 Pyrococcus furiosus
2.7.7.6 pol III
-
 Sulfolobus acidocaldarius
2.7.7.6 pol III
-
 Saccharolobus solfataricus
2.7.7.6 pol III
-
 Methanocaldococcus jannaschii
2.7.7.6 pol III
-
 Emiliania huxleyi
2.7.7.6 pol III
-
 Cenarchaeum symbiosum
2.7.7.6 pol III
-
 Nanoarchaeum equitans
2.7.7.6 pol III
-
 Caldivirga maquilingensis
2.7.7.6 pol III
-
 Thermofilum pendens
2.7.7.6 pol III
-
 Nitrosopumilus maritimus
2.7.7.6 RNA polymerase II
-
 Saccharomyces cerevisiae

General Information

EC Number General Information Comment Organism
2.7.7.6 additional information structure-based analysis of the evolution of archaeal and eukaryotic DNA-dependent RNA polymerases, overview Escherichia coli
2.7.7.6 additional information structure-based analysis of the evolution of archaeal and eukaryotic DNA-dependent RNA polymerases, overview Saccharomyces cerevisiae
2.7.7.6 additional information structure-based analysis of the evolution of archaeal and eukaryotic DNA-dependent RNA polymerases, overview Pyrococcus furiosus
2.7.7.6 additional information structure-based analysis of the evolution of archaeal and eukaryotic DNA-dependent RNA polymerases, overview Sulfolobus acidocaldarius
2.7.7.6 additional information structure-based analysis of the evolution of archaeal and eukaryotic DNA-dependent RNA polymerases, overview Saccharolobus solfataricus
2.7.7.6 additional information structure-based analysis of the evolution of archaeal and eukaryotic DNA-dependent RNA polymerases, overview Methanocaldococcus jannaschii
2.7.7.6 additional information structure-based analysis of the evolution of archaeal and eukaryotic DNA-dependent RNA polymerases, overview Emiliania huxleyi
2.7.7.6 additional information structure-based analysis of the evolution of archaeal and eukaryotic DNA-dependent RNA polymerases, overview Nanoarchaeum equitans
2.7.7.6 additional information structure-based analysis of the evolution of archaeal and eukaryotic DNA-dependent RNA polymerases, overview Caldivirga maquilingensis
2.7.7.6 additional information structure-based analysis of the evolution of archaeal and eukaryotic DNA-dependent RNA polymerases, overview Thermofilum pendens
2.7.7.6 physiological function RNA polymerase II has a regulatory function on nucleoside triphosphate synthesis, mutations of RNA polymerase II activate key genes of the nucleoside triphosphate biosynthetic pathways, overview Saccharomyces cerevisiae