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Literature summary extracted from

  • Calao, M.; Burny, A.; Quivy, V.; Dekoninck, A.; Van Lint, C.
    A pervasive role of histone acetyltransferases and deacetylases in an NF-kappaB-signaling code (2008), Trends Biochem. Sci., 33, 339-349.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.48 IKKalpha after cytokine stimulation, IKKalpha also phosphorylates CBP at Ser1382 and Ser1386, thus enhancing CBP-binding affinity for p65 and CBP HAT activity and, consequently, histone H3 acetylation Mammalia
2.3.1.48 additional information CBP is activated by phosphorylation at Ser1382 and Ser1386 Mammalia
2.3.1.48 p65 p65-associated HAT activity. TNFalpha-dependent phosphorylation of p65 at either Ser276 or Ser536 increases its interaction with p300 and its subsequent acetylation at Lys310 of the NFkappaB subunit, indicating that p65 phosphorylation regulates subsequent acetylation Mammalia

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.48 additional information PPARgamma suppresses eotaxin, an NF-kappaB target, gene expression by direct inhibition of p65-associated HAT activity, for example, by competing with p65 for limited amounts of CBP and/or by recruiting HDAC to the p65-HAT complex Mammalia

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.48 additional information recruitment of HATs and HDACs by IkappaBalpha, IKKalpha and IKKgamma Mammalia
-
-
2.3.1.48 nucleus
-
 Mammalia 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.48 acetyl-CoA + histone H3 Mammalia regulation, detailed overview. Acetylation and deacetylation events, in combination with other post-translational protein modifications, generate an NF-kappaB-signaling code and regulate NF-kappaB-dependent gene transcription in an inducer- and promoter-dependent manner, overview CoA + acetylhistone H3
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.48 Mammalia
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.3.1.48 phosphoprotein IKKalpha phosphorylates and activates CBP at Ser1382 and Ser1386 Mammalia

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.48 acetyl-CoA + histone H3 regulation, detailed overview. Acetylation and deacetylation events, in combination with other post-translational protein modifications, generate an NF-kappaB-signaling code and regulate NF-kappaB-dependent gene transcription in an inducer- and promoter-dependent manner, overview Mammalia CoA + acetylhistone H3
-
 r
2.3.1.48 acetyl-CoA + histone H3
-
 Mammalia CoA + acetylhistone H3
-
 r
2.3.1.48 acetyl-CoA + NF-kB p65 acetylation of the subunit at Lys310 by p300 or PCAF Mammalia CoA + acetyl-NF-kB p65
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.48 Cbp
-
 Mammalia
2.3.1.48 HAT
-
 Mammalia

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.48 acetyl-CoA
-
 Mammalia

General Information

EC Number General Information Comment Organism
2.3.1.48 metabolism histone and non-histone protein acetylation is involved, directly and indirectly, in controlling the duration, strength and specificity of the NF-kappaB-activating signaling pathway at multiple levels. Overview of the NF-kB-signaling pathway. Different signaling pathways can interfere with one another by modulating the availability of HATs or HDACs for a particular transcription complex Mammalia
2.3.1.48 physiological function histone and non-histone protein acetylation is involved, directly and indirectly, in controlling the duration, strength and specificity of the NF-kappaB-activating signaling pathway at multiple levels. Overview of the NF-kB-signaling pathway, IkappaBalpha and some members of the IKK complex have a nuclear function involving HAT and HDAC recruitment Mammalia