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Literature summary extracted from

  • Hammad, S.M.; Crellin, H.G.; Wu, B.X.; Melton, J.; Anelli, V.; Obeid, L.M.
    Dual and distinct roles for sphingosine kinase 1 and sphingosine 1 phosphate in the response to inflammatory stimuli in RAW macrophages (2008), Prostaglandins Other Lipid Mediat., 85, 107-114.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.91 lipopolysaccharide increases Sk1 transcription which is accompanied by increased SK activity and generation of sphingosine 1-phosphate. Sphingosine 1-phosphate is able to cause increases in COX-2 and PGE2 levels in RAW cells Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.91 Mus musculus
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-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.91 RAW-264.7 cell
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 Mus musculus
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General Information

EC Number General Information Comment Organism
2.7.1.91 physiological function knock-down of SK1 using siRNA is able to inhibit the TNF but not the lipopolysaccharide inflammatory response. Knock-down of SK1 enhances both TNF- and lipopolysaccharide-induced apoptosis Mus musculus