Literature summary extracted from

Orlova, I.; Nagegowda, D.A.; Kish, C.M.; Gutensohn, M.; Maeda, H.; Varbanova, M.; Fridman, E.; Yamaguchi, S.; Hanada, A.; Kamiya, Y.; Krichevsky, A.; Citovsky, V.; Pichersky, E.; Dudareva, N.
The small subunit of snapdragon geranyl diphosphate synthase modifies the chain length specificity of tobacco geranylgeranyl diphosphate synthase in planta (2009), Plant Cell, 21, 4002-4017.

Protein Variants

EC Number	Protein Variants	Comment	Organism
2.5.1.29	additional information	geranyl phosphate synthase small subunit of Antirrhinum majus forms chimeric geranyl phosphate synthases with geranylgeranyl diphosphate synthase GGPPS1 or GGPPS2 in Nicotiana tabacum. The formation of chimeric GPPS in transgenic plants also results in leaf chlorosis, increased light sensitivity, and dwarfism due to decreased levels of chlorophylls, carotenoids, and gibberellins. Transgenic plants have reduced levels of sesquiterpene emission	Antirrhinum majus
2.5.1.29	additional information	isoforms GGPPS2 and GGPPS1 can form functional heterodimers with heterologously expressed geranyl phosphate synthase small subunit of Antirrhinum majus. The formation of chimeric GPPS in transgenic plants also results in leaf chlorosis, increased light sensitivity, and dwarfism due to decreased levels of chlorophylls, carotenoids, and gibberellins. Transgenic plants have reduced levels of sesquiterpene emission	Nicotiana tabacum

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism
2.5.1.29	0.00236	-	geranyl diphosphate	GGPPS2	Nicotiana tabacum
2.5.1.29	0.00363	-	geranyl diphosphate	GGPPS1	Nicotiana tabacum
2.5.1.29	0.0093	-	isopentenyl diphosphate	heterodimer of geranyl phosphate synthase small subunit of Antirrhinum majus with Nicotiana tabacum geranylgeranyl diphosphate synthase GGPPS1	Antirrhinum majus
2.5.1.29	0.0093	-	isopentenyl diphosphate	heterodimer of GGPPS1 with geranyl phosphate synthase small subunit of Antirrhinum majus	Nicotiana tabacum
2.5.1.29	0.0155	-	dimethylallyl diphosphate	GGPPS2	Nicotiana tabacum
2.5.1.29	0.0195	-	dimethylallyl diphosphate	cosubstrate geranyl diphosphate, GGPPS2	Nicotiana tabacum
2.5.1.29	0.0197	-	dimethylallyl diphosphate	cosubstrate geranyl diphosphate, GGPPS1	Nicotiana tabacum
2.5.1.29	0.0201	-	dimethylallyl diphosphate	cosubstrate farnesyl diphosphate, GGPPS2	Nicotiana tabacum
2.5.1.29	0.0206	-	isopentenyl diphosphate	GGPPS1	Nicotiana tabacum
2.5.1.29	0.0206	-	isopentenyl diphosphate	GGPPS2	Nicotiana tabacum
2.5.1.29	0.0206	-	isopentenyl diphosphate	heterodimer of geranyl phosphate synthase small subunit of Antirrhinum majus with Nicotiana tabacum geranylgeranyl diphosphate synthase GGPPS1	Antirrhinum majus
2.5.1.29	0.0206	-	isopentenyl diphosphate	heterodimer of GGPPS2 with geranyl phosphate synthase small subunit of Antirrhinum majus	Nicotiana tabacum
2.5.1.29	0.0228	-	dimethylallyl diphosphate	GGPPS1	Nicotiana tabacum
2.5.1.29	0.0277	-	dimethylallyl diphosphate	cosubstrate farnesyl diphosphate, GGPPS1	Nicotiana tabacum
2.5.1.29	0.0288	-	farnesyl diphosphate	GGPPS1	Nicotiana tabacum
2.5.1.29	0.029	-	dimethylallyl diphosphate	heterodimer of geranyl phosphate synthase small subunit of Antirrhinum majus with Nicotiana tabacum geranylgeranyl diphosphate synthase GGPPS2	Antirrhinum majus
2.5.1.29	0.029	-	dimethylallyl diphosphate	heterodimer of GGPPS2 with geranyl phosphate synthase small subunit of Antirrhinum majus	Nicotiana tabacum
2.5.1.29	0.0532	-	farnesyl diphosphate	GGPPS2	Nicotiana tabacum
2.5.1.29	0.0589	-	dimethylallyl diphosphate	heterodimer of geranyl phosphate synthase small subunit of Antirrhinum majus with Nicotiana tabacum geranylgeranyl diphosphate synthase GGPPS2	Antirrhinum majus
2.5.1.29	0.0589	-	dimethylallyl diphosphate	heterodimer of GGPPS1 with geranyl phosphate synthase small subunit of Antirrhinum majus	Nicotiana tabacum

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
2.5.1.29	plastid	-	Nicotiana tabacum	9536	-
2.5.1.29	plastid	-	Antirrhinum majus	9536	-

Metals/Ions

EC Number	Metals/Ions	Comment	Organism	Structure
2.5.1.29	MgCl2	Km value 0.51 mM for isoform GGPPS1, 0.19 mM for isoform GGPPS2	Nicotiana tabacum

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.5.1.29	Antirrhinum majus	-	-	-
2.5.1.29	Nicotiana tabacum	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
2.5.1.29	(E,E)-farnesyl diphosphate + isopentenyl diphosphate	isoforms TC5826 and TC11329, i.e. GGPPS2 and GGPPS1, respectively	Nicotiana tabacum	diphosphate + geranylgeranyl diphosphate	-	?
2.5.1.29	dimethylallyl diphosphate + 3 isopentenyl diphosphate	-	Antirrhinum majus	geranylgeranyl diphosphate + 3 diphosphate	-	?
2.5.1.29	dimethylallyl diphosphate + 3 isopentenyl diphosphate	isoforms TC5826 and TC11329, i.e. GGPPS2 and GGPPS1, respectively	Nicotiana tabacum	geranylgeranyl diphosphate + diphosphate	-	?
2.5.1.29	geranyl diphosphate + 2 isopentenyl diphosphate	isoforms TC5826 and TC11329, i.e. GGPPS2 and GGPPS1, respectively	Nicotiana tabacum	geranylgeranyl diphosphate + diphosphate	-	?

Subunits

EC Number	Subunits	Comment	Organism
2.5.1.29	More	geranyl phosphate synthase small subunit of Antirrhinum majus forms chimeric geranyl phosphate synthases with geranylgeranyl diphosphate synthase GGPPS1 or GGPPS2 in Nicotiana tabacum	Antirrhinum majus
2.5.1.29	More	isoforms GGPPS2 and GGPPS! can form functional heterodimers with heterologously expressed geranyl phosphate synthase small subunit of Antirrhinum majus	Nicotiana tabacum