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Literature summary extracted from

  • Wakasa, K.; Ishihara, A.
    Metabolic engineering of the tryptophan and phenylalanine biosynthetic pathways in rice (2009), Plant Biotechnol., 26, 523-533.
No PubMed abstract available

Application

EC Number Application Comment Organism
4.2.1.91 industry fine tuning of the feedback sensitivity of ADT may be effective to establish a line that accumulate Phe at a high concentration Oryza sativa

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.1.91 overexpression of the mutant gene in rice calli Oryza sativa

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.91 additional information wild-type enzyme is sensitive to feedback inhibition by Phe, but the mutant enzyme encoded by mtr1-D is relatively insensitive Oryza sativa

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.91 Oryza sativa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.1.91 callus
-
 Oryza sativa
-
4.2.1.91 pollen
-
 Oryza sativa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.91 L-arogenate prefers arogenate as substrate, its catalytic efficiency with arogenate is about 10fold higher than that with prephenate Oryza sativa L-phenylalanine + CO2 + H2O
-
 ?
4.2.1.91 prephenate
-
 Oryza sativa phenylpyruvate + CO2 + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.91 ADT/PDT
-
 Oryza sativa
4.2.1.91 arogenate dehydratase/prephenate dehydratase
-
 Oryza sativa
4.2.1.91 Mtr1
-
 Oryza sativa

General Information

EC Number General Information Comment Organism
4.2.1.91 malfunction the rice mtr1 mutant accumulates Phe and Trp. Calli overexpressing mtr1 mutant show elevated levels of Phe, Trp, phenylpropanoids and an indole alkaloid, and is resistant to 5-methyltryptophan treatment. Mtr1 mutants display the same short culm and reduced spikelet number that are observed in transgenic rice accumulating Trp, but Mtr1 mutants show slightly better germination frequency and spikelet fertility Oryza sativa
4.2.1.91 metabolism Mtr1 encoding enzyme ADT/PDT catalyzes the final reaction in Phe biosynthesis and is critical for regulating the size of Phe pool in plant cells. Mtr1 callus contains a high level of secondary metabolites including phenylpropanoids and indole alkaloid, but these do not have a significant effect on the rest of the plant's morphological and other agronomic characteristics Oryza sativa