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Literature summary extracted from

  • Schmit, T.L.; Ledesma, M.C.; Ahmad, N.
    Modulating polo-like kinase 1 as a means for cancer chemoprevention (2010), Pharm. Res., 27, 989-998.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.21 aurora A Plk1 activity is increased upon phosphorylation at threonine-210 by Aurora A in conjunction with Bora Mammalia
2.7.11.21 Bora Plk1 activity is increased upon phosphorylation at threonine-210 by Aurora A in conjunction with Bora Mammalia

Application

EC Number Application Comment Organism
2.7.11.21 medicine Plk1 may be a useful target for cancer chemoprevention Mammalia

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.21 genistein decreases Plk1 expression Mammalia
2.7.11.21 indirubin decreases Plk1 expression Mammalia
2.7.11.21 morin enzymatic inhibitor Mammalia
2.7.11.21 purpurogallin polo box inhibitor Mammalia
2.7.11.21 quercetin enzymatic inhibitor Mammalia
2.7.11.21 scytonemin enzymatic inhibitor Mammalia
2.7.11.21 silibinin decreases Plk1 expression Mammalia
2.7.11.21 staurosporine enzymatic inhibitor Mammalia
2.7.11.21 thymoquinone polo box inhibitor Mammalia
2.7.11.21 trichostatin A decreases Plk1 expression Mammalia
2.7.11.21 Vanillin decreases Plk1 expression Mammalia
2.7.11.21 Wortmannin enzymatic inhibitor Mammalia

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.21 ATP + a protein Mammalia
-
 ADP + a phosphoprotein
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.21 Mammalia
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.21 phosphoprotein
-
 Mammalia

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.21 ATP + a protein
-
 Mammalia ADP + a phosphoprotein
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.21 Plk1
-
 Mammalia
2.7.11.21 Polo-like kinase 1
-
 Mammalia

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.21 ATP
-
 Mammalia

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.11.21 0.000024
-
-
 Mammalia Wortmannin
2.7.11.21 0.0008
-
-
 Mammalia staurosporine
2.7.11.21 0.002
-
-
 Mammalia scytonemin
2.7.11.21 0.0126
-
-
 Mammalia morin
2.7.11.21 0.064
-
-
 Mammalia quercetin

Expression

EC Number Organism Comment Expression
2.7.11.21 Mammalia decline upon mitotic exit into G1 down
2.7.11.21 Mammalia Plk1 mRNA, protein and activity levels begin to rise in S-phase, peaking at the G2/M transition, over-expressed in a variety of cancers up

General Information

EC Number General Information Comment Organism
2.7.11.21 physiological function Plk1 plays several crucial roles in cell cycle progression and cell division Mammalia