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Literature summary extracted from

  • Occhipinti, A.; Berlicki, L.; Giberti, S.; Dziedziola, G.; Kafarski, P.; Forlani, G.
    Effectiveness and mode of action of phosphonate inhibitors of plant glutamine synthetase (2010), Pest Manag. Sci., 66, 51-58.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.1.2 [[(2,3-dichlorophenyl)amino]methanediyl]bis(phosphonic acid) non-competitive mechanism against glutamate and uncompetitive mechanism against ATP Zea mays
6.3.1.2 [[(2,4-dichlorophenyl)amino]methanediyl]bis(phosphonic acid) non-competitive mechanism against glutamate and uncompetitive mechanism against ATP Zea mays
6.3.1.2 [[(2,6-dichlorophenyl)amino]methanediyl]bis(phosphonic acid) non-competitive mechanism against glutamate and uncompetitive mechanism against ATP Zea mays
6.3.1.2 [[(3,5-dichlorophenyl)amino]methanediyl]bis(phosphonic acid) non-competitive mechanism against glutamate and uncompetitive mechanism against ATP Zea mays
6.3.1.2 [[(4-chlorophenyl)amino]methanediyl]bis(phosphonic acid) non-competitive mechanism against glutamate and uncompetitive mechanism against ATP Zea mays

Organism

EC Number Organism UniProt Comment Textmining
6.3.1.2 Zea mays P38561
-
-

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
6.3.1.2 0.0076
-
-
 Zea mays [[(3,5-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
6.3.1.2 0.0128
-
-
 Zea mays [[(2,3-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
6.3.1.2 0.015
-
-
 Zea mays [[(2,6-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
6.3.1.2 0.021
-
-
 Zea mays [[(4-chlorophenyl)amino]methanediyl]bis(phosphonic acid)
6.3.1.2 0.0212
-
-
 Zea mays [[(2,4-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)