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Literature summary extracted from

  • Leifert, W.; Abeywardena, M.
    Grape seed and red wine polyphenol extracts inhibit cellular cholesterol uptake, cell proliferation, and 5-lipoxygenase activity (2008), Nutr. Res., 28, 729-737.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.13.11.34 0.015
-
 arachidonic acid
-
 Glycine max
1.13.11.34 0.039
-
 linoleic acid
-
 Glycine max

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.13.11.34 Fe2+ ferrous form of LO-1 Glycine max

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.34 Glycine max
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.34 arachidonate + O2 higher affinity of arachidonate than linoleic acid for the ferrous form of lipoxygenase-1. Hydrogen abstraction step displays high kinetic isotope effects on kcat due to tunneling contributions. Lack of solvent-dependent rate-limiting steps at lower temperatures with arachidonate as substrate Glycine max (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate
-
 ?
1.13.11.34 linoleic acid + O2 lower affinity of linoleic acid than arachidonic acid for the ferrous form of lipoxygenase-1. Hydrogen abstraction step displays high kinetic isotope effects on kcat due to tunneling contributions Glycine max ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.34 lipoxygenase-1
-
 Glycine max
1.13.11.34 LO-1
-
 Glycine max

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
1.13.11.34 31000
-
 arachidonic acid at 25°C Glycine max