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Literature summary extracted from

  • Panova, N.; Alexeev, C.; Polyakov, K.; Gavryushov, S.; Kritzyn, A.; Mikhailov, S.
    Substrate specificity of thymidine phosphorylase of E. coli: role of hydroxyl groups (2008), Nucleosides Nucleotides Nucleic Acids, 27, 1211-1214.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.4 additional information inhibitory nucleotide derivatives, overview Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.4 thymidine + phosphate Escherichia coli
-
 thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.4 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.4 additional information the 3'-OH group is important for nucleotide binding, substrate analogues and substrate specificity, overview Escherichia coli ?
-
 ?
2.4.2.4 thymidine + phosphate
-
 Escherichia coli thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
 r
2.4.2.4 thymidine + phosphate substrate binding induces domain movement, which leads to the closed conformation of the active site and initiates phosphorylation, molecular dynamic simulation, overview Escherichia coli thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
 r

Subunits

EC Number Subunits Comment Organism
2.4.2.4 More three-dimensional enzyme structure by molecular dynamic simulation Escherichia coli

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.2.4 37
-
 assay at Escherichia coli

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.2.4 6.5
-
 assay at Escherichia coli

General Information

EC Number General Information Comment Organism
2.4.2.4 metabolism the enzyme participates in the thymidine salvage pathway maintaining the thymidine pool in the cell Escherichia coli