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Literature summary extracted from

  • Archambault, V.; Glover, D.
    Polo-like kinases: Conservation and divergence in their functions and regulation (2009), Nat. Rev. Mol. Cell Biol., 10, 265-275.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.21 additional information activated by phosphorylation Drosophila melanogaster
2.7.11.21 additional information activated by phosphorylation Homo sapiens
2.7.11.21 additional information activated by phosphorylation Saccharomyces cerevisiae
2.7.11.21 additional information activated by phosphorylation Xenopus laevis
2.7.11.21 additional information activated by phosphorylation Saccharomyces pombe

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.21 ATP + a protein Drosophila melanogaster
-
ADP + a phosphoprotein
-
?
2.7.11.21 ATP + a protein Homo sapiens
-
ADP + a phosphoprotein
-
?
2.7.11.21 ATP + a protein Saccharomyces cerevisiae
-
ADP + a phosphoprotein
-
?
2.7.11.21 ATP + a protein Xenopus laevis
-
ADP + a phosphoprotein
-
?
2.7.11.21 ATP + a protein Saccharomyces pombe
-
ADP + a phosphoprotein
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.21 Drosophila melanogaster
-
-
-
2.7.11.21 Homo sapiens
-
-
-
2.7.11.21 Saccharomyces cerevisiae
-
-
-
2.7.11.21 Saccharomyces pombe
-
-
-
2.7.11.21 Xenopus laevis
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.21 phosphoprotein
-
Drosophila melanogaster
2.7.11.21 phosphoprotein
-
Homo sapiens
2.7.11.21 phosphoprotein
-
Saccharomyces cerevisiae
2.7.11.21 phosphoprotein
-
Xenopus laevis
2.7.11.21 phosphoprotein
-
Saccharomyces pombe

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.21 ATP + a protein
-
Drosophila melanogaster ADP + a phosphoprotein
-
?
2.7.11.21 ATP + a protein
-
Homo sapiens ADP + a phosphoprotein
-
?
2.7.11.21 ATP + a protein
-
Saccharomyces cerevisiae ADP + a phosphoprotein
-
?
2.7.11.21 ATP + a protein
-
Xenopus laevis ADP + a phosphoprotein
-
?
2.7.11.21 ATP + a protein
-
Saccharomyces pombe ADP + a phosphoprotein
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.21 Cdc5
-
Saccharomyces cerevisiae
2.7.11.21 PLK
-
Drosophila melanogaster
2.7.11.21 PLK
-
Homo sapiens
2.7.11.21 Plo1
-
Saccharomyces pombe
2.7.11.21 Plx1
-
Xenopus laevis
2.7.11.21 polo-like kinase
-
Drosophila melanogaster
2.7.11.21 polo-like kinase
-
Homo sapiens
2.7.11.21 polo-like kinase
-
Saccharomyces cerevisiae
2.7.11.21 polo-like kinase
-
Xenopus laevis
2.7.11.21 polo-like kinase
-
Saccharomyces pombe

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.21 ATP
-
Drosophila melanogaster
2.7.11.21 ATP
-
Homo sapiens
2.7.11.21 ATP
-
Saccharomyces cerevisiae
2.7.11.21 ATP
-
Xenopus laevis
2.7.11.21 ATP
-
Saccharomyces pombe

Expression

EC Number Organism Comment Expression
2.7.11.21 Homo sapiens up-regulated in many tumors up

General Information

EC Number General Information Comment Organism
2.7.11.21 physiological function Plks are potent regulators of M phase, their roles in mitotic entry, spindle pole functions and cytokinesis are broadly conserved Drosophila melanogaster
2.7.11.21 physiological function Plks are potent regulators of M phase, their roles in mitotic entry, spindle pole functions and cytokinesis are broadly conserved Homo sapiens
2.7.11.21 physiological function Plks are potent regulators of M phase, their roles in mitotic entry, spindle pole functions and cytokinesis are broadly conserved Saccharomyces cerevisiae
2.7.11.21 physiological function Plks are potent regulators of M phase, their roles in mitotic entry, spindle pole functions and cytokinesis are broadly conserved Xenopus laevis
2.7.11.21 physiological function Plks are potent regulators of M phase, their roles in mitotic entry, spindle pole functions and cytokinesis are broadly conserved Saccharomyces pombe