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Literature summary extracted from

  • George Cisar, E.A.; Geisinger, E.; Muir, T.W.; Novick, R.P.
    Symmetric signalling within asymmetric dimers of the Staphylococcus aureus receptor histidine kinase AgrC (2009), Mol. Microbiol., 74, 44-57.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.13.3 auto-inducible protein I dose-dependent activation by autoinducing peptide Staphylococcus aureus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.13.3 G394A/G396A completely inactive Staphylococcus aureus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.13.3 ATP + protein L-histidine Staphylococcus aureus
-
 ADP + protein N-phospho-L-histidine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.13.3 Staphylococcus aureus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.13.3 phosphoprotein AgrC forms ligand-independent dimers that undergo trans-autophosphorylation upon interaction with autoinducing peptide Staphylococcus aureus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.13.3 ATP + protein L-histidine
-
 Staphylococcus aureus ADP + protein N-phospho-L-histidine
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.13.3 dimer AgrC forms ligand-independent dimers that undergo trans-autophosphorylation upon interaction with autoinducing peptide Staphylococcus aureus

Synonyms

EC Number Synonyms Comment Organism
2.7.13.3 AgrC
-
 Staphylococcus aureus
2.7.13.3 receptor histidine kinase
-
 Staphylococcus aureus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.13.3 ATP
-
 Staphylococcus aureus

General Information

EC Number General Information Comment Organism
2.7.13.3 physiological function the AgrC receptor histidine kinase detects its autoinducing peptide ligand and generates an intracellular signal resulting in secretion of virulence factors Staphylococcus aureus