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Literature summary extracted from

  • Gurvitz, A.
    The essential mycobacterial genes, fabG1 and fabG4, encode 3-oxoacyl-thioester reductases that are functional in yeast mitochondrial fatty acid synthase type 2 (2009), Mol. Genet. Genomics, 282, 407-416.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.100 expression in Streptomyces cerevisiae cells lacking 3-oxoacyl-ACP reductase Mycobacterium tuberculosis
1.1.1.100 FabG1 expressed from vector pPLM189 as mitochondrial protein in the Saccharomyces cerevisiae oar1DELTA mutant strain. FabG1 can restore respiratory growth of Saccharomyces cerevisiae oar1DELTA cells and renews lipoic acid production Mycobacterium tuberculosis
1.1.1.100 FabG4 expressed from vector pPLM192 as mitochondrial protein in the Saccharomyces cerevisiae oar1DELTA mutant strain. FabG4 can restore respiratory growth of Saccharomyces cerevisiae oar1DELTA cells and renews lipoic acid production Mycobacterium tuberculosis
2.3.1.85 expressed in Saccharomyces cerevisiae oar1DELTA cells Mycobacterium tuberculosis

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.100 additional information oar1-DELTA mutants, lack 3-oxoacyl-ACP reductase acitivity, expression of FabG4 gene of Mycobacterium tuberculosis Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.100 soluble
-
 Saccharomyces cerevisiae
-
-
1.1.1.100 soluble
-
 Mycobacterium tuberculosis
-
-
2.3.1.85 mitochondrion
-
 Mycobacterium tuberculosis 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.100 Mycobacterium tuberculosis
-
-
-
1.1.1.100 Mycobacterium tuberculosis O53665
-
-
1.1.1.100 Mycobacterium tuberculosis P9WGT3
-
-
1.1.1.100 Mycobacterium tuberculosis H37Rv P9WGT3
-
-
1.1.1.100 Saccharomyces cerevisiae
-
-
-
2.3.1.85 Mycobacterium tuberculosis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.100 additional information FabG1 is able to act on shorter (C4) acyl substrates Mycobacterium tuberculosis ?
-
 ?
1.1.1.100 additional information FabG1 is able to act on shorter (C4) acyl substrates Mycobacterium tuberculosis H37Rv ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.100 3-oxoacyl-AcpM reductase
-
 Mycobacterium tuberculosis
1.1.1.100 3-oxoacyl-thioester reductase
-
 Saccharomyces cerevisiae
1.1.1.100 3-oxoacyl-thioester reductase
-
 Mycobacterium tuberculosis
1.1.1.100 FabG1
-
 Mycobacterium tuberculosis
1.1.1.100 fabG4
-
 Saccharomyces cerevisiae
1.1.1.100 fabG4
-
 Mycobacterium tuberculosis
2.3.1.85 FASII
-
 Mycobacterium tuberculosis
2.3.1.85 fatty acid synthase type 2 3-oxoacyl-acyl carrier protein reductase FabG1/Rv1483 is a component of the fatty acid synthase type 2 system Mycobacterium tuberculosis
2.3.1.85 type 2 dissociative FAS
-
 Mycobacterium tuberculosis