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Literature summary extracted from

  • Maccarana, M.; Kalamajski, S.; Kongsgaard, M.; Magnusson, S.P.; Oldberg, A.; Malmstroem, A.
    Dermatan sulfate epimerase 1-deficient mice have reduced content and changed distribution of iduronic acids in dermatan sulfate and an altered collagen structure in skin (2009), Mol. Cell. Biol., 29, 5517-5528.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.1.3.19 D-glucuronate Mus musculus
-
 L-iduronate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.1.3.19 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.1.3.19 brain
-
 Mus musculus
-
5.1.3.19 kidney
-
 Mus musculus
-
5.1.3.19 lung
-
 Mus musculus
-
5.1.3.19 additional information expression levels of wild-type, heterozygous and homozygous enzyme mutants, overview Mus musculus
-
5.1.3.19 skin
-
 Mus musculus
-
5.1.3.19 spleen
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.1.3.19 D-glucuronate
-
 Mus musculus L-iduronate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.1.3.19 dermatan sulfate epimerase 1
-
 Mus musculus
5.1.3.19 DS-epi1
-
 Mus musculus
5.1.3.19 DS-epi2
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
5.1.3.19 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
5.1.3.19 5.5
-
 assay at Mus musculus

Expression

EC Number Organism Comment Expression
5.1.3.19 Mus musculus generation of DS-epi1-null mice, the mutant mice show alterations in the chondroitin/dermatan polysaccharide chains. The numbers of long blocks of adjacent iduronic acids are greatly decreased in skin decorin and biglycan chondroitin/dermatan sulfate, along with a parallel decrease in iduronic-2-O-sulfated-galactosamine-4-O-sulfated structures. Both iduronic acid blocks and iduronic acids surrounded by glucuronic acids are also decreased in versican-derived chains. DS-epi1-deficient mice are smaller than their wild-type littermates but otherwise have no gross macroscopic alterations, DS-epi1-null fibrils have a larger diameter than the wild-type fibrils, phenotypes, overview additional information

General Information

EC Number General Information Comment Organism
5.1.3.19 malfunction DS-epi1 deficiency alters skin morphology, collagen fibril ultrastructure, and skin tensile strength, phenotype, overview Mus musculus