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Literature summary extracted from

  • Zhang, Y.; Bai, L.; Deng, Z.
    Functional characterization of the first two actinomycete 4-amino-4-deoxychorismate lyase genes (2009), Microbiology, 155, 2450-2459.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.3.38 expressed in Escherichia coli BL21(DE3) cells Streptomyces sp.

Protein Variants

EC Number Protein Variants Comment Organism
4.1.3.38 additional information a mutant with pabC-1 inactivated still retains about 20% of the wild type level of antibiotic FR-008 production, pabC-1/pabC-2 double mutation severely reduces antibiotic FR-008 production and renders the mutant p-aminobenzoic acid-auxotrophic Streptomyces sp.
4.1.3.38 additional information pabC-1/pabC-2 double mutation severely reduces antibiotic FR-008 production and renders the mutant p-aminobenzoic acid-auxotrophic Streptomyces sp.

Organism

EC Number Organism UniProt Comment Textmining
4.1.3.38 Streptomyces sp.
-
-
-
4.1.3.38 Streptomyces sp. B8Y8J0 PabC-2
-
4.1.3.38 Streptomyces sp. FR-008
-
-
-
4.1.3.38 Streptomyces sp. FR-008 B8Y8J0 PabC-2
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.3.38 nickel affinity column chromatography Streptomyces sp.

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.3.38 4-amino-4-deoxychorismate
-
 Streptomyces sp. 4-aminobenzoate + pyruvate
-
 ?
4.1.3.38 4-amino-4-deoxychorismate
-
 Streptomyces sp. FR-008 4-aminobenzoate + pyruvate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.3.38 4-amino-4-deoxychorismate lyase
-
 Streptomyces sp.
4.1.3.38 ADC lyase
-
 Streptomyces sp.
4.1.3.38 PabC-1
-
 Streptomyces sp.
4.1.3.38 PabC-2
-
 Streptomyces sp.

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.3.38 pyridoxal 5'-phosphate
-
 Streptomyces sp.