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Literature summary extracted from

  • Katz, L.
    The DEBS paradigm for type I modular polyketide synthases and beyond (2009), Methods Enzymol., 459, 113-142.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.94 propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+ Saccharopolyspora erythraea
-
 6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.94 Saccharopolyspora erythraea
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.94 propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+
-
 Saccharopolyspora erythraea 6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.94 More DEBS is organized into modules comprising of multiple catalytic domains, to assemble short acyl-CoA precursors into complex polyketide products, each module contains minimally three functional domains, a beta-ketosynthase, KS, an acyltransferase, AT, and an acyl carrier protein, ACP Saccharopolyspora erythraea

Synonyms

EC Number Synonyms Comment Organism
2.3.1.94 6-deoxyerythronolide B
-
 Saccharopolyspora erythraea
2.3.1.94 DEBS
-
 Saccharopolyspora erythraea
2.3.1.94 PKS
-
 Saccharopolyspora erythraea
2.3.1.94 polyketide synthase
-
 Saccharopolyspora erythraea