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Literature summary extracted from
- Overexpression of isocitrate lyase-glyoxylate bypass influence on metabolism in Aspergillus niger (2009), Metab. Eng., 11, 107-116.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 4.1.3.1 | into vector pCR2.1-AfpyrG and overexpressed in the pyrA-strain AB4.1 | Aspergillus niger |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.3.1 | Aspergillus niger | - |
- |
- |
| 4.1.3.1 | Aspergillus niger N402 | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.3.1 | isocitrate | - |
Aspergillus niger | succinate + glyoxylate | - |
? |  |
| 4.1.3.1 | isocitrate | - |
Aspergillus niger N402 | succinate + glyoxylate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.1.3.1 | ICL | - |
Aspergillus niger |
| 4.1.3.1 | isocitrate lyase | - |
Aspergillus niger |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 4.1.3.1 | metabolism | ICL overexpression and malonate addition has a significant impact on metabolism and on organic acid production profiles. Increased ICL expression does not result in an increased glyoxylate bypass flux, there is a global response with respect to gene expression, leading to an increased flux through the oxidative part of the TCA cycle. Instead of an increased production of succinate and malate, a major increase in fumarate production is observed. In the strain with overexpression of ICL the organic acid production shifts from fumarate towards malate production when malonate is added to the cultivation medium | Aspergillus niger |
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Release 2023.1 (January 2023)
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