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Literature summary extracted from

  • Wang, Y.; Pfeifer, B.
    6-Deoxyerythronolide B production through chromosomal localization of the deoxyerythronolide B synthase genes in E. coli (2008), Metab. Eng., 10, 33-38.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.3.1.94 biotechnology a new Escherichia coli stain, YW9, is created, featuring a plasmid-free heterologous pathway for the production of the polyketide product 6-deoxyerythronolide B Saccharopolyspora erythraea

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.94 the three DEBS genes are sequentially integrated into the Escherichia coli BAP1 chromosome Saccharopolyspora erythraea

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.94 propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+ Saccharopolyspora erythraea
-
 6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.94 Saccharopolyspora erythraea
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.94 propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+
-
 Saccharopolyspora erythraea 6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.94 DEBS
-
 Saccharopolyspora erythraea
2.3.1.94 deoxyerythronolide B synthase
-
 Saccharopolyspora erythraea