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Literature summary extracted from

  • Cheng, Y.; Liu, F.; Wu, J.; Zhang, Y.; Nilsson, A.; Duan, R.D.
    Ezetimibe inhibits expression of acid sphingomyelinase in liver and intestine (2009), Lipids, 44, 897-906.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Homo sapiens
-
-
-
3.1.4.12 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 Caco-2 cell
-
Homo sapiens
-
3.1.4.12 Hep-G2 cell
-
Homo sapiens
-
3.1.4.12 intestine
-
Rattus norvegicus
-
3.1.4.12 liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 sphingomyelin + H2O
-
Homo sapiens N-acylsphingosine + choline phosphate
-
?
3.1.4.12 sphingomyelin + H2O
-
Rattus norvegicus N-acylsphingosine + choline phosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 A-SMase
-
Homo sapiens
3.1.4.12 A-SMase
-
Rattus norvegicus
3.1.4.12 acid SMase
-
Homo sapiens
3.1.4.12 acid SMase
-
Rattus norvegicus
3.1.4.12 acid sphingomyelinase
-
Homo sapiens
3.1.4.12 acid sphingomyelinase
-
Rattus norvegicus
3.1.4.12 alk-SMase
-
Homo sapiens
3.1.4.12 alk-SMase
-
Rattus norvegicus
3.1.4.12 alkaline SMase
-
Homo sapiens
3.1.4.12 alkaline SMase
-
Rattus norvegicus
3.1.4.12 N-SMase
-
Homo sapiens
3.1.4.12 N-SMase
-
Rattus norvegicus
3.1.4.12 neutral sphingomyelinase
-
Homo sapiens
3.1.4.12 neutral sphingomyelinase
-
Rattus norvegicus

Expression

EC Number Organism Comment Expression
3.1.4.12 Homo sapiens acid SMase protein is decreased by 20% in both Hep-G2 and Caco-2 cells at 0.1 mM ezetimibe down
3.1.4.12 Rattus norvegicus acid SMase protein is decreased by 25% in the intestine and by 34% in the liver at 0.1 mM ezetimibe down
3.1.4.12 Homo sapiens ezetimibe up to 0.05 mM has no effects on acid phosphatase activity in both Hep-G2 and Caco-2 cells, no change of alkaline phosphatase activity is identified by ezetimibe additional information