EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.4.12 | Homo sapiens | - |
- |
- |
3.1.4.12 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.4.12 | Caco-2 cell | - |
Homo sapiens | - |
3.1.4.12 | Hep-G2 cell | - |
Homo sapiens | - |
3.1.4.12 | intestine | - |
Rattus norvegicus | - |
3.1.4.12 | liver | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.4.12 | sphingomyelin + H2O | - |
Homo sapiens | N-acylsphingosine + choline phosphate | - |
? | |
3.1.4.12 | sphingomyelin + H2O | - |
Rattus norvegicus | N-acylsphingosine + choline phosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.4.12 | A-SMase | - |
Homo sapiens |
3.1.4.12 | A-SMase | - |
Rattus norvegicus |
3.1.4.12 | acid SMase | - |
Homo sapiens |
3.1.4.12 | acid SMase | - |
Rattus norvegicus |
3.1.4.12 | acid sphingomyelinase | - |
Homo sapiens |
3.1.4.12 | acid sphingomyelinase | - |
Rattus norvegicus |
3.1.4.12 | alk-SMase | - |
Homo sapiens |
3.1.4.12 | alk-SMase | - |
Rattus norvegicus |
3.1.4.12 | alkaline SMase | - |
Homo sapiens |
3.1.4.12 | alkaline SMase | - |
Rattus norvegicus |
3.1.4.12 | N-SMase | - |
Homo sapiens |
3.1.4.12 | N-SMase | - |
Rattus norvegicus |
3.1.4.12 | neutral sphingomyelinase | - |
Homo sapiens |
3.1.4.12 | neutral sphingomyelinase | - |
Rattus norvegicus |
EC Number | Organism | Comment | Expression |
---|---|---|---|
3.1.4.12 | Homo sapiens | acid SMase protein is decreased by 20% in both Hep-G2 and Caco-2 cells at 0.1 mM ezetimibe | down |
3.1.4.12 | Rattus norvegicus | acid SMase protein is decreased by 25% in the intestine and by 34% in the liver at 0.1 mM ezetimibe | down |
3.1.4.12 | Homo sapiens | ezetimibe up to 0.05 mM has no effects on acid phosphatase activity in both Hep-G2 and Caco-2 cells, no change of alkaline phosphatase activity is identified by ezetimibe | additional information |