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Literature summary extracted from

  • Profita, M.; Bonanno, A.; Siena, L.; Bruno, A.; Ferraro, M.; Montalbano, A.M.; Albano, G.D.; Riccobono, L.; Casarosa, P.; Pieper, M.P.; Gjomarkaj, M.
    Smoke, choline acetyltransferase, muscarinic receptors, and fibroblast proliferation in chronic obstructive pulmonary disease (2009), J. Pharmacol. Exp. Ther., 329, 753-763.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.6 acetyl-CoA + choline Homo sapiens
-
 CoA + O-acetylcholine acetylcholine is the primary parasympathetic neurotransmitter in the airways ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.6 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.6 fibroblast lung, fetal lung fibroblasts, HFL-1 Homo sapiens
-
2.3.1.6 HFL-1 cell
-
 Homo sapiens
-
2.3.1.6 lung
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.6 acetyl-CoA + choline
-
 Homo sapiens CoA + O-acetylcholine
-
 ?
2.3.1.6 acetyl-CoA + choline
-
 Homo sapiens CoA + O-acetylcholine acetylcholine is the primary parasympathetic neurotransmitter in the airways ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.6 ChAT
-
 Homo sapiens
2.3.1.6 choline acetyltransferase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.6 acetyl-CoA
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.3.1.6 Homo sapiens interleukin-1beta induces the enzyme in HFL-1 cells up

General Information

EC Number General Information Comment Organism
2.3.1.6 malfunction in cigarette smokers and patients with chronic obstructive pulmonary disease, acetylcholine activation in lung fibroblasts causes increased cell proliferation involving muscarinic M1, M2, and M3 receptors, and ERK1/2 and NFkappaB pathways, overview Homo sapiens
2.3.1.6 physiological function acetylcholine, synthesized by ChAT, and muscarinic M1, M2, and M3 receptors are involved in fibroblast proliferation Homo sapiens