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Literature summary extracted from

  • Pardin, C.; Pelletier, J.N.; Lubell, W.D.; Keillor, J.W.
    Cinnamoyl inhibitors of tissue transglutaminase (2008), J. Org. Chem., 73, 5766-5775.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.2.13
-
 Cavia porcellus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.2.13 (2E)-3-(4-nitrophenyl)-1-(pyridin-3-yl)prop-2-en-1-one reversible, competitive with the acyl donor substrate Cavia porcellus
2.3.2.13 1-[(2E)-3-(4-nitrophenyl)prop-2-enoyl]-3H-[1,2,3]triazolo[4,5-b]pyridin-1-ium-3-olate reversible, competitive with the acyl donor substrate Cavia porcellus
2.3.2.13 3-[(2E)-3-(3-nitrophenyl)prop-2-enoyl]-1H-benzotriazol-3-ium-1-olate reversible, competitive with the acyl donor substrate Cavia porcellus
2.3.2.13 fluorenylmethyl [4-[(1E)-3-(1H-benzotriazol-1-yl)-3-oxoprop-1-en-1-yl]phenyl]carbamate reversible, competitive with the acyl donor substrate Cavia porcellus
2.3.2.13 methyl 4-[(1E)-3-(1H-benzotriazol-1-yl)-3-oxoprop-1-en-1-yl]benzoate reversible, competitive with the acyl donor substrate Cavia porcellus
2.3.2.13 N-[4-[(1E)-3-oxo-3-(pyridin-3-yl)prop-1-en-1-yl]phenyl]acetamide reversible, competitive with the acyl donor substrate Cavia porcellus
2.3.2.13 tert-butyl [4-[(1E)-3-(1H-benzotriazol-1-yl)-3-oxoprop-1-en-1-yl]phenyl]carbamate reversible, competitive with the acyl donor substrate Cavia porcellus

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.13 Cavia porcellus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.2.13 liver
-
 Cavia porcellus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.13 N-Cbz-Glu(gamma-p-nitrophenyl ester)Gly + ?
-
 Cavia porcellus ?
-
 ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.2.13 0.018
-
 pH 7.0, 25 Cavia porcellus tert-butyl [4-[(1E)-3-(1H-benzotriazol-1-yl)-3-oxoprop-1-en-1-yl]phenyl]carbamate
2.3.2.13 0.021
-
 pH 7.0, 25 Cavia porcellus (2E)-3-(4-nitrophenyl)-1-(pyridin-3-yl)prop-2-en-1-one
2.3.2.13 0.024
-
 pH 7.0, 25 Cavia porcellus 3-[(2E)-3-(3-nitrophenyl)prop-2-enoyl]-1H-benzotriazol-3-ium-1-olate
2.3.2.13 0.025
-
 pH 7.0, 25 Cavia porcellus fluorenylmethyl [4-[(1E)-3-(1H-benzotriazol-1-yl)-3-oxoprop-1-en-1-yl]phenyl]carbamate
2.3.2.13 0.027
-
 pH 7.0, 25 Cavia porcellus methyl 4-[(1E)-3-(1H-benzotriazol-1-yl)-3-oxoprop-1-en-1-yl]benzoate
2.3.2.13 0.028
-
 pH 7.0, 25 Cavia porcellus N-[4-[(1E)-3-oxo-3-(pyridin-3-yl)prop-1-en-1-yl]phenyl]acetamide
2.3.2.13 0.033
-
 pH 7.0, 25 Cavia porcellus 1-[(2E)-3-(4-nitrophenyl)prop-2-enoyl]-3H-[1,2,3]triazolo[4,5-b]pyridin-1-ium-3-olate