Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Burgess, A.; Saini, S.; Weng, Y.Q.; Aubert, I.
    Stimulation of choline acetyltransferase by C3d, a neural cell adhesion molecule ligand (2009), J. Neurosci. Res., 87, 609-616.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.6 C3d a neural cell adhesion molecule ligand, 65-74% activation at 0.001 mM involving the fibroblast growth factor receptor, activation is inhibited by the FGFR inhibitor, SU5402 Rattus norvegicus

Application

EC Number Application Comment Organism
2.3.1.6 medicine promoting ChAT activity and acetylcholine release can lead to treatments for neurodegenerative diseases with cholinergic deficits, such as Alzheimer’s disease Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.6 acetyl-CoA + choline Rattus norvegicus
-
 CoA + O-acetylcholine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.6 Rattus norvegicus
-
 Sprague Dawley rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.6 hippocampus
-
 Rattus norvegicus
-
2.3.1.6 neuron septal cholinergic Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.6 acetyl-CoA + choline
-
 Rattus norvegicus CoA + O-acetylcholine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.6 ChAT
-
 Rattus norvegicus
2.3.1.6 choline acetyltransferase
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.6 37
-
 assay at Rattus norvegicus