Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Ghoddoussi, F.; Galloway, M.; Jambekar, A.; Bame, M.; Needleman, R.; Brusilow, W.
    Methionine sulfoximine, an inhibitor of glutamine synthetase, lowers brain glutamine and glutamate in a mouse model of ALS (2010), J. Neurol. Sci., 290, 41-47.
    View publication on PubMed

Application

EC Number Application Comment Organism
6.3.1.2 medicine treatment with methionine sulfoximine of transgenic mice that overexpresses the mutant human superoxide dismutase SOD1G93A gene, an animalmodel for the primary inherited form of the human neurodegenerative disease amyotrophic lateral sclerosis. This treatment in vivo reduces glutamine synthetase activity measured in vitro by 85% and reduces brain levels of glutamine by 60% and of glutamate by 30% in both the motor cortex and the anterior striatum, while also affecting levels of GABA and glutathione. Methionine sulfoxime treatment significantly extends the lifespan of these mice by 8% Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.1.2 methionine sulfoximine treatment with methionine sulfoximine of transgenic mice that overexpresses the mutant human superoxide dismutase SOD1G93A gene, an animalmodel for the primary inherited form of the human neurodegenerative disease amyotrophic lateral sclerosis. This treatment in vivo reduces glutamine synthetase activity measured in vitro by 85% and reduces brain levels of glutamine by 60% and of glutamate by 30% in both the motor cortex and the anterior striatum, while also affecting levels of GABA and glutathione. Methionine sulfoxime treatment significantly extends the lifespan of these mice by 8% Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
6.3.1.2 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.1.2 brain
-
 Mus musculus
-
6.3.1.2 corpus striatum anterior corpus striatum Mus musculus
-
6.3.1.2 motor cortex
-
 Mus musculus
-