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Literature summary extracted from

  • Lovering, A.L.; De Castro, L.; Strynadka, N.C.
    Identification of dynamic structural motifs involved in peptidoglycan glycosyltransfer (2008), J. Mol. Biol., 383, 167-177.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.129 expressed in Escherichia coli Rosetta lambdaDE3 cells Staphylococcus aureus

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.4.1.129 sitting drop vapor diffusion method, using 100 mM HEPES, pH 7.5, 2 M ammonium sulfate, 20% (v/v) ethylene glycol and 0.28 mM lauryldimethylamine oxide Staphylococcus aureus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.129 Moenomycin
-
 Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.129 Staphylococcus aureus
-
-
-
2.4.1.129 Staphylococcus aureus NCTC 8325
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.1.129 Ni2+-affinity column chromatography, gel filtration, and Mono Q ion-exchange chromatography Staphylococcus aureus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.129 [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n-diphosphoundecaprenol + GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
 Staphylococcus aureus [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n+1-diphosphoundecaprenol + undecaprenyl diphosphate
-
 ?
2.4.1.129 [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n-diphosphoundecaprenol + GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
 Staphylococcus aureus NCTC 8325 [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n+1-diphosphoundecaprenol + undecaprenyl diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.129 PBP2
-
 Staphylococcus aureus
2.4.1.129 penicillin-binding protein 2 bifunctional peptidoglycan glycosyltransferase/transpeptidase Staphylococcus aureus