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Literature summary extracted from

  • Jain, S.; Zhang, X.; Khandelwal, P.J.; Saunders, A.J.; Cummings, B.S.; Oelkers, P.
    Characterization of human lysophospholipid acyltransferase 3 (2009), J. Lipid Res., 50, 1563-1570.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.23 expressed in Sf9 insect cell Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.23 0.0021
-
 stearoyl-CoA 37°C, cooperativity: Hill number 3.7 Homo sapiens
2.3.1.23 0.0051
-
 stearoyl-CoA 28°C, cooperativity: Hill number 2.7 Homo sapiens
2.3.1.23 0.0122
-
 oleoyl-CoA 37°C, cooperativity: Hill number 1.6 Homo sapiens
2.3.1.23 0.0131
-
 lysophosphatidylcholine cooperativity: Hill number 1.7 Homo sapiens
2.3.1.23 0.0465
-
 oleoyl-CoA 28°C, cooperativity: Hill number 2.0 Homo sapiens
2.3.1.23 0.0558
-
 Arachidonoyl-CoA 28°C, cooperativity: Hill number 2.0 Homo sapiens
2.3.1.23 0.214
-
 alpha-linolenoyl-CoA 28°C, no cooperativity: Hill number 1.0 Homo sapiens
2.3.1.23 0.232
-
 stearoyl-CoA 37°C, cooperativity: Hill number 1.4 Homo sapiens
2.3.1.23 0.245
-
 Arachidonoyl-CoA 37°C, cooperativity: Hill number 2.0 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.23 56000
-
 x * 56000, predicted Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.23 Homo sapiens Q6P1A2
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.23 HEK-293 cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.23 0.006
-
 substrate: stearoyl-CoA, 37°C, cooperativity: Hill number 3.7 Homo sapiens
2.3.1.23 0.05
-
 substrate: stearoyl-CoA, 28°C, cooperativity: Hill number 2.7 Homo sapiens
2.3.1.23 0.082
-
 substrate: arachidonoyl-CoA, 37°C, cooperativity: Hill number 2.0 Homo sapiens
2.3.1.23 0.087
-
 substrate: oleoyl-CoA, 37°C, cooperativity: Hill number 1.6 Homo sapiens
2.3.1.23 0.268
-
 substrate: alpha-linolenoyl-CoA, 28°C, no cooperativity: Hill number 1.0 Homo sapiens
2.3.1.23 0.323
-
 substrate: stearoyl-CoA, 37°C, cooperativity: Hill number 1.4 Homo sapiens
2.3.1.23 0.486
-
 substrate: lysophosphatidylcholine, cooperativity: Hill number 1.7 Homo sapiens
2.3.1.23 0.529
-
 substrate: arachidonoyl-CoA, 28°C, cooperativity: Hill number 2.0 Homo sapiens
2.3.1.23 0.759
-
 substrate: oleoyl-CoA, 28°C, cooperativity: Hill number 2.0 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.23 1-palmitoyl-2-lysophosphatidylcholine + alpha-linolenoyl-CoA
-
 Homo sapiens 1-palmitoyl-2-alpha-linolenoylphosphatidylcholine + CoA
-
 ?
2.3.1.23 1-palmitoyl-2-lysophosphatidylcholine + arachidonoyl-CoA
-
 Homo sapiens 1-palmitoyl-2-arachidonoylphosphatidylcholine + CoA
-
 ?
2.3.1.23 1-palmitoyl-2-lysophosphatidylcholine + oleoyl-CoA
-
 Homo sapiens 1-palmitoyl-2-oleoylphosphatidylcholine + CoA
-
 ?
2.3.1.23 1-palmitoyl-2-lysophosphatidylcholine + stearoyl-CoA
-
 Homo sapiens 1-palmitoyl-2-stearoylphosphatidylcholine + CoA
-
 ?
2.3.1.23 additional information reduced activity with lysophosphatidylethanolamine and lysophosphatidylserine Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.23 ? x * 56000, predicted Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.3.1.23 LPCAT3
-
 Homo sapiens
2.3.1.23 lysophosphatidylcholine acyltransferase 3
-
 Homo sapiens

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
2.3.1.23 0.005
-
 Arachidonoyl-CoA 37°C, cooperativity: Hill number 2.0 Homo sapiens
2.3.1.23 0.02
-
 alpha-linolenoyl-CoA 28°C, no cooperativity: Hill number 1.0 Homo sapiens
2.3.1.23 0.02
-
 stearoyl-CoA 37°C, cooperativity: Hill number 1.4 Homo sapiens
2.3.1.23 0.04
-
 stearoyl-CoA 37°C, cooperativity: Hill number 3.7 Homo sapiens
2.3.1.23 0.12
-
 oleoyl-CoA 37°C, cooperativity: Hill number 1.6 Homo sapiens
2.3.1.23 0.16
-
 Arachidonoyl-CoA 28°C, cooperativity: Hill number 2.0 Homo sapiens
2.3.1.23 0.16
-
 stearoyl-CoA 28°C, cooperativity: Hill number 2.7 Homo sapiens
2.3.1.23 0.27
-
 oleoyl-CoA 28°C, cooperativity: Hill number 2.0 Homo sapiens