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Literature summary extracted from

  • Saito, A.; Sato, T.; Okano, H.; Toyoda, K.; Bamba, H.; Kimura, S.; Bellier, J.P.; Matsuo, A.; Kimura, H.; Hisa, Y.; Tooyama, I.
    Axotomy alters alternative splicing of choline acetyltransferase in the rat dorsal motor nucleus of the vagus nerve (2009), J. Comp. Neurol., 513, 237-248.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.6 cDNAs encoding splicing variants cChAT and pChAT, purified from the rat striatum and pterygopalatine ganglion, respectively, expression analysis. Recombinant expression in HEK-293 cells Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.6 acetyl-CoA + choline Rattus norvegicus
-
 CoA + O-acetylcholine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.6 Rattus norvegicus
-
 two splicing variants, peripheral-type pChAT and common-type cChAT
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.6 brain cChAT and pChAt expression analysis in brain, overview Rattus norvegicus
-
2.3.1.6 additional information after axotomy pChAT immunoreactivity is apparent in some brainstem nuclei, such as the dorsal motor nucleus of the vagus nerve, the nucleus ambiguus, and the hypoglossal nucleus, but not in the brainstem neurons of normal rats Rattus norvegicus
-
2.3.1.6 vagus nerve dorsal motor nucleus of the vagus nerve, contains a peripheral-type pChAT, a splice variant that lacks exons 6-9 of the common-type ChAT, cChAT Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.6 acetyl-CoA + choline
-
 Rattus norvegicus CoA + O-acetylcholine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.6 ChAT
-
 Rattus norvegicus
2.3.1.6 choline acetyltransferase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.6 acetyl-CoA
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
2.3.1.6 Rattus norvegicus pChAT expression is induced by neuronal damage up