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Literature summary extracted from

  • Meares, G.P.; Hughes, K.J.; Jaimes, K.F.; Salvatori, A.S.; Rhodes, C.J.; Corbett, J.A.
    AMP-activated protein kinase attenuates nitric oxide-induced beta-cell death (2010), J. Biol. Chem., 285, 3191-3200.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.31 5-aminoimidazole-4-carboxamide riboside AICAR, increases phosphorylation of acetyl-CoA carboxylase and AMPK in INS832/13 cells Rattus norvegicus
2.7.11.31 Diethylamine NONOate nitric oxide donor, stimulates rapid and transient AMPK phosphorylation in INS832/13 cells and islets Rattus norvegicus
2.7.11.31 interleukin-1 induces nitric oxide-dependent activation of AMPK Rattus norvegicus
2.7.11.31 nitric oxide AMPK is transiently activated by nitric oxide in insulinoma cells and rat islets following interleukin-1 treatment or by the exogenous addition of nitric oxide Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.31 adenoviral expression of wild-type, dominant negative or constitutively active AMPK mutants. Transduction of INS832/13 cells Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.31 H150R constitutively active AMPKgamma1 mutant, stimulates the concentration-dependent increase of substrate phosphorylation Rattus norvegicus
2.7.11.31 K45R dominant negative AMPKalpha2 mutant, results in a concentration-dependent inhibition in the phosphorylation of the AMPK substrate, inhibits endogenous AMPK activation. Inhibition of AMPK attenuates recovery of aconitase activity and promotes caspase-3 activation during recovery Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.31 Rattus norvegicus
-
 male sprague-dawley rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.31 insulinoma cell
-
 Rattus norvegicus
-
2.7.11.31 additional information islet, INS832/13 cells Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.31 ATP + acetyl-CoA carboxylase
-
 Rattus norvegicus ADP + [acetyl-CoA carboxylase]phosphate
-
 ?
2.7.11.31 additional information AMPK promotes reactivation of mitochondrial aconitase Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.31 AMP-activated protein kinase
-
 Rattus norvegicus
2.7.11.31 AMPK
-
 Rattus norvegicus

General Information

EC Number General Information Comment Organism
2.7.11.31 metabolism active AMPK promotes the functional recovery of beta-cell oxidative metabolism and abrogates the induction of pathways that mediate cell death such as caspase-3 activation following exposure to nitric oxide Rattus norvegicus