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Literature summary extracted from

  • Koike, S.; Keino-Masu, K.; Ohto, T.; Sugiyama, F.; Takahashi, S.; Masu, M.
    Autotaxin/lysophospholipase D-mediated lysophosphatidic acid signaling is required to form distinctive large lysosomes in the visceral endoderm cells of the mouse yolk sac (2009), J. Biol. Chem., 284, 33561-33570.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.39 lysophosphatidylcholine + H2O Mus musculus
-
lysophosphatidic acid + choline
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.39 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.39 yolk sac from E7.5 to E9.5, Enpp2 mRNA is abundantly expressed in the visceral endoderm cells Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.39 lysophosphatidylcholine + H2O
-
Mus musculus lysophosphatidic acid + choline
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.39 ATX
-
Mus musculus
3.1.4.39 autotaxin
-
Mus musculus
3.1.4.39 lysophospholipase D
-
Mus musculus

General Information

EC Number General Information Comment Organism
3.1.4.39 malfunction in Enpp2 knockout mouse embryos, lysosomes in the visceral endoderm cells are fragmented Mus musculus
3.1.4.39 physiological function constitutive activationof the Rho-ROCK-LIM kinase pathway by extracellular production of lysophosphatidic acid by the action of autotaxin is required to maintain the large size of lysosomes in visceral endoderm cells Mus musculus