EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.4.39 | lysophosphatidylcholine + H2O | Mus musculus | - |
lysophosphatidic acid + choline | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.4.39 | Mus musculus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.4.39 | yolk sac | from E7.5 to E9.5, Enpp2 mRNA is abundantly expressed in the visceral endoderm cells | Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.4.39 | lysophosphatidylcholine + H2O | - |
Mus musculus | lysophosphatidic acid + choline | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.4.39 | ATX | - |
Mus musculus |
3.1.4.39 | autotaxin | - |
Mus musculus |
3.1.4.39 | lysophospholipase D | - |
Mus musculus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.1.4.39 | malfunction | in Enpp2 knockout mouse embryos, lysosomes in the visceral endoderm cells are fragmented | Mus musculus |
3.1.4.39 | physiological function | constitutive activationof the Rho-ROCK-LIM kinase pathway by extracellular production of lysophosphatidic acid by the action of autotaxin is required to maintain the large size of lysosomes in visceral endoderm cells | Mus musculus |