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Literature summary extracted from

  • Kamenecka, T.; Habel, J.; Duckett, D.; Chen, W.; Ling, Y.Y.; Frackowiak, B.; Jiang, R.; Shin, Y.; Song, X.; LoGrasso, P.
    Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38 (2009), J. Biol. Chem., 284, 12853-12861.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.24 a pDEST_JNK3_39-402 construct is used for the expression of the protein in Escherichia coli BL21DE3 cells Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.11.24 the structure of SR3737 and SR3451-soaked JNK3 crystals are solved at 2.20 and 2.29 A, respectively Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.24 SR3451
-
 Homo sapiens
2.7.11.24 SR3451
-
 Mammalia
2.7.11.24 SR3576
-
 Homo sapiens
2.7.11.24 SR3576
-
 Mammalia
2.7.11.24 SR3582
-
 Homo sapiens
2.7.11.24 SR3582
-
 Mammalia
2.7.11.24 SR3583
-
 Homo sapiens
2.7.11.24 SR4018
-
 Homo sapiens
2.7.11.24 SR4018
-
 Mammalia
2.7.11.24 SR4276
-
 Homo sapiens
2.7.11.24 SR4276
-
 Mammalia
2.7.11.24 SR4326
-
 Homo sapiens
2.7.11.24 SR4326
-
 Mammalia
2.7.11.24 SR4642
-
 Homo sapiens
2.7.11.24 SR4642
-
 Mammalia
2.7.11.24 SR4643
-
 Homo sapiens
2.7.11.24 SR4643
-
 Mammalia

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.24 ATP + a protein Homo sapiens
-
 ADP + a phosphoprotein
-
 ?
2.7.11.24 ATP + a protein Mammalia
-
 ADP + a phosphoprotein
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.24 Homo sapiens
-
-
-
2.7.11.24 Mammalia
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.24 a SP Fastflow column, a Mono S column, and a Sephacryl S200 column are used Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.24 ATP + a protein
-
 Homo sapiens ADP + a phosphoprotein
-
 ?
2.7.11.24 ATP + a protein
-
 Mammalia ADP + a phosphoprotein
-
 ?
2.7.11.24 ATP + ATF-2
-
 Homo sapiens ADP + phosphorylated ATF-2
-
 ?
2.7.11.24 ATP + c-Jun
-
 Homo sapiens ADP + phosphorylated c-Jun
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.24 c-jun N-terminal kinase 1
-
 Mammalia
2.7.11.24 c-Jun N-terminal kinase 3
-
 Homo sapiens
2.7.11.24 JNK1
-
 Mammalia
2.7.11.24 JNK3
-
 Homo sapiens
2.7.11.24 p38 mitogen-activated protein kinase
-
 Mammalia
2.7.11.24 p38MAPK
-
 Mammalia

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.24 ATP
-
 Homo sapiens
2.7.11.24 ATP
-
 Mammalia

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.11.24 0.000007
-
-
 Homo sapiens SR3576
2.7.11.24 0.000023
-
-
 Homo sapiens SR3582
2.7.11.24 0.000025
-
-
 Homo sapiens SR3451
2.7.11.24 0.000055
-
-
 Homo sapiens SR4326
2.7.11.24 0.00017
-
-
 Mammalia SR3576
2.7.11.24 0.00035
-
-
 Homo sapiens SR4276
2.7.11.24 0.0004
-
-
 Mammalia SR3451
2.7.11.24 0.00048
-
-
 Homo sapiens SR3583
2.7.11.24 0.00056
-
-
 Mammalia SR3582
2.7.11.24 0.0014
-
-
 Mammalia SR4326
2.7.11.24 0.0015
-
-
 Homo sapiens SR4643
2.7.11.24 0.0021
-
-
 Homo sapiens SR4018
2.7.11.24 0.0022
-
-
 Homo sapiens SR4642
2.7.11.24 0.0037
-
-
 Mammalia SR3451
2.7.11.24 0.02
-
 larger than 0.020 Mammalia SR4642
2.7.11.24 0.02
-
 larger than 0.020 Mammalia SR4643
2.7.11.24 0.02
-
 larger than 0.020 Mammalia SR4018
2.7.11.24 0.02
-
 larger than 0.020 Mammalia SR3582
2.7.11.24 0.02
-
 larger than 0.020 Mammalia SR3576
2.7.11.24 0.02
-
 larger than 0.020 Mammalia SR4326
2.7.11.24 0.02
-
 larger than 0.020 Mammalia SR4276