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Literature summary extracted from

  • Qin, S.; De Vries, G.W.
    alpha2 But not alpha1 AMP-activated protein kinase mediates oxidative stress-induced inhibition of retinal pigment epithelium cell phagocytosis of photoreceptor outer segments (2008), J. Biol. Chem., 283, 6744-6751.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.31 5-aminoimidazole-4-carboxamide riboside AICAR, its activation of AMPK is abolished by preincubation with dipyridamole or 5-iodotubercidin Homo sapiens
2.7.11.31 hydrogen peroxide sublethal oxidative stress inhibits retinal pigment epithelium cell phagocytosis and activates AMPK. 0.5 mM hydrogen peroxide dramatically activates AMPKalpha, reaches the peak within 15 min, and declines 1 h later. Thr172 phosphorylation of catalytic subunit AMPKalpha is required for AMPKalpha activation Homo sapiens

Application

EC Number Application Comment Organism
2.7.11.31 drug development activating AMPK may have therapeutic potential in treating dry macular degeneration Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.31 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.31 ARPE-19 cell
-
 Homo sapiens
-
2.7.11.31 retinal pigment epithelium alpha1 AMPK is the dominant isoform Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.31 ATP + acetyl-CoA carboxylase AMPKalpha can phosphorylate Ser79 of acetyl-CoA carboxylase Homo sapiens ADP + [acetyl-CoA carboxylase]phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.31 AMP-activated protein kinase
-
 Homo sapiens
2.7.11.31 AMPK
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.7.11.31 Homo sapiens alpha1 and alpha2 AMPK siRNAs selectively suppress AMPKalpha1 and AMPKalpha2 protein, respectively. AMPKalpha1 and AMPKalpha2 proteins are reduced to 6 and 1% of respective controls. Combined treatment with both alpha1 and alpha2 AMPK siRNAs lead to 66 and 92% reduction of AMPKalpha1 and AMPKalpha2 protein, respectively down
2.7.11.31 Homo sapiens AMPKalpha1 repression causes a 37% compensational increase in AMPKalpha2 protein up

General Information

EC Number General Information Comment Organism
2.7.11.31 physiological function AMPK activation during oxidative stress may switch retinal pigment epithelium cells to a self-protected status. Alpha2 but not alpha1 AMPK is involved in retinal pigment epithelium cell phagocytosis and activation of alpha2 AMPK contributes to the inhibition of retinal pigment epithelium cell phagocytosis by oxidative stress Homo sapiens