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Literature summary extracted from

  • Kramer, D.; Diegelman, P.; Jell, J.; Vujcic, S.; Merali, S.; Porter, C.
    Polyamine acetylation modulates polyamine metabolic flux, a prelude to broader metabolic consequences (2008), J. Biol. Chem., 283, 4241-4251.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.57 SSAT overexpression in prostate cancer cells leads to a massive increase in intracellular and extracellular acetylated spermidine and to a 6-20fold increase in biosynthetic enzyme activities, overview. In the presence of 4-fluoro-ornithine, SSAT overexpression leads to the sequential appearance of fluorinated putrescine, spermidine, acetylated spermidine, and spermine Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.57 cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.57 3 acetyl-CoA + 2 spermine Homo sapiens
-
 3 CoA + N1-acetylspermine + N1,N12-diacetylspermine
-
 ?
2.3.1.57 acetyl-CoA + spermidine Homo sapiens
-
 CoA + N1-acetylspermidine
-
 ?
2.3.1.57 additional information Homo sapiens SSAT induction increased metabolic flux by about 5fold, overview. The metabolic flux can be interrupted by inhibition of polyamine biosynthesis but not by inhibition of polyamine oxidation ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.57 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.57 3 acetyl-CoA + 2 spermine
-
 Homo sapiens 3 CoA + N1-acetylspermine + N1,N12-diacetylspermine
-
 ?
2.3.1.57 acetyl-CoA + spermidine
-
 Homo sapiens CoA + N1-acetylspermidine
-
 ?
2.3.1.57 additional information SSAT induction increased metabolic flux by about 5fold, overview. The metabolic flux can be interrupted by inhibition of polyamine biosynthesis but not by inhibition of polyamine oxidation Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.57 spermidine/spermine N1-acetyltransferase
-
 Homo sapiens
2.3.1.57 SSAT
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.57 acetyl-CoA
-
 Homo sapiens