EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.1.1.356 | F679Y | the mutant is tolerated with about 2fold reduction compared with wild type | Drosophila melanogaster |
2.1.1.356 | F679Y | the mutant retains the capacity to produce trimethylated histone H3(K27) | Drosophila melanogaster |
2.1.1.356 | F681Y | the mutation dramatically reduces PRC2 HMTase | Drosophila melanogaster |
2.1.1.356 | additional information | each SET domain mutation disrupts PRC2 histone methyltransferase, based on known SET domain structures, the mutations likely affect either the lysine-substrate binding pocket, the binding site for the adenosylmethionine methyl donor, or a critical tyrosine predicted to interact with the substrate lysine epsilon-amino group. The CXC mutant retains catalytic activity, Lys-27 specificity, and trimethylation capacity. | Drosophila melanogaster |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.356 | Drosophila melanogaster | - |
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EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.356 | S-adenosyl-L-methionine + histone H3(K27) | di- and trimethylation at histone H3(K27) | Drosophila melanogaster | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.1.356 | histone lysine methyltransferase | - |
Drosophila melanogaster |
2.1.1.356 | HMTase | - |
Drosophila melanogaster |
2.1.1.356 | Polycomb repressive complex 2 | - |
Drosophila melanogaster |
2.1.1.356 | PRC2 | - |
Drosophila melanogaster |