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Literature summary extracted from

  • Yazaki, K.; Kunihisa, M.; Fujisaki, T.; Sato, F.
    Geranyl diphosphate:4-hydroxybenzoate geranyltransferase from Lithospermum erythrorhizon. Cloning and characterization of a ket enzyme in shikonin biosynthesis (2001), J. Biol. Chem., 277, 6240-6246.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.93 functional expression of LePGTs in a yeast COQ2 disruptant Lithospermum erythrorhizon

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5.1.93 0.0051
-
geranyl diphosphate
-
Lithospermum erythrorhizon
2.5.1.93 0.0103
-
4-hydroxybenzoate
-
Lithospermum erythrorhizon
2.5.1.93 0.0459
-
geranyl diphosphate
-
Lithospermum erythrorhizon
2.5.1.93 0.0538
-
4-hydroxybenzoate
-
Lithospermum erythrorhizon

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.93 geranyl diphosphate + 4-hydroxybenzoate Lithospermum erythrorhizon
-
3-geranyl-4-hydroxybenzoate + diphosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.93 Lithospermum erythrorhizon Q8W404
-
-
2.5.1.93 Lithospermum erythrorhizon Q8W405
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.93 root the mRNA of the LePGT-1 gene is undetectable in aerial plant tissues, and is exclusively detected in root tissues, similar to shikonin accumulation Lithospermum erythrorhizon
-
2.5.1.93 root the mRNA of the LePGT-2 gene is undetectable in aerial plant tissues, and is exclusively detected in root tissues, similar to shikonin accumulation Lithospermum erythrorhizon
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.93 geranyl diphosphate + 4-hydroxybenzoate
-
Lithospermum erythrorhizon 3-geranyl-4-hydroxybenzoate + diphosphate
-
?
2.5.1.93 geranyl diphosphate + 4-hydroxybenzoate the enzyme accepts only geranyl diphosphate and not dimethylallyl diphosphate, farnesyl diphosphate, or geranylgeranyl diphosphate as the substrate Lithospermum erythrorhizon 3-geranyl-4-hydroxybenzoate + diphosphate
-
?
2.5.1.93 geranyl diphosphate + 4-hydroxybenzoate the enzyme accepts only geranyl-diphosphate and not dimethylallyl diphosphate, farnesyl diphosphate, or geranylgeranyl diphosphate as the substrate Lithospermum erythrorhizon 3-geranyl-4-hydroxybenzoate + diphosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.93 4HB:geranyltransferase
-
Lithospermum erythrorhizon
2.5.1.93 geranyl diphosphate:4-hydroxybenzoate geranyltransferase
-
Lithospermum erythrorhizon
2.5.1.93 LePGT-1
-
Lithospermum erythrorhizon
2.5.1.93 LePGT-2
-
Lithospermum erythrorhizon