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Literature summary extracted from

  • Hondorp, E.R.; Matthews, R.G.
    Oxidation of cysteine 645 of cobalamin-independent methionine synthase causes a methionine limitation in Escherichia coli (2009), J. Bacteriol., 191, 3407-3410.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.14 expressed in Escherichia coli strain MTD23 Escherichia coli

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.14 C645A the mutation confers resistance to diamide when cells are grown in media lacking methionine, but not when cells are grown in the presence of methionine, cysteine 645 serves to modulate the activity of MetE in vivo in response to disulfide stress Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.14 Diamide
-
 Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.14 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.14 5-methyltetrahydropteroyl-tri-L-glutamate + L-homocysteine
-
 Escherichia coli tetrahydropteroyl-tri-L-glutamate + L-methionine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.14 cobalamin-independent methionine synthase
-
 Escherichia coli
2.1.1.14 MetE
-
 Escherichia coli