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Literature summary extracted from

  • Chatterjee, I.; Kriegeskorte, A.; Fischer, A.; Deiwick, S.; Theimann, N.; Proctor, R.; Peters, G.; Herrmann, M.; Kahl, B.
    In vivo mutations of thymidylate synthase (encoded by thyA) are responsible for thymidine dependency in clinical small-colony variants of Staphylococcus aureus (2008), J. Bacteriol., 190, 834-842.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.45 expressed in Escherichia coli Staphylococcus aureus

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.45 additional information mutations of the thyA gene are responsible for the phenotype of trimethoprim-sulfamethoxazole-resistant thymidine-dependent small-colony variants of Staphylococcus aureus Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.45 Staphylococcus aureus
-
 wild type strain 8325-4 and trimethoprim-sulfamethoxazole-resistant thymidine-dependent small-colony variants 1-8
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP
-
 Staphylococcus aureus dihydrofolate + dTMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.45 ThyA
-
 Staphylococcus aureus

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.45 N5,N10-methylenetetrahydrofolate
-
 Staphylococcus aureus