Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Fujita, Y.; Murakami, R.; Muramatsu, Y.; Miyakoshi, S.; Takatsu, T.
    A-94964, novel inhibitor of bacterial translocase I, produced by Streptomyces sp. SANK 60404. II. Physico-chemical properties and structure elucidation (2008), J. Antibiot., 61, 545-549.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.8.13 medicine translocase I is a target of antibiotics Staphylococcus aureus
2.7.8.13 medicine translocase I is a target of antibiotics Enterococcus faecalis

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.8.13 A-94964
-
 Enterococcus faecalis
2.7.8.13 A-94964
-
 Staphylococcus aureus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.13 UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate Staphylococcus aureus
-
 UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
 ?
2.7.8.13 UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate Enterococcus faecalis
-
 UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.13 Enterococcus faecalis
-
-
-
2.7.8.13 Staphylococcus aureus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.13 UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
-
 Staphylococcus aureus UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
 ?
2.7.8.13 UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
-
 Enterococcus faecalis UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.8.13 phospho-N-acetylmuramyl-pentapeptide translocase
-
 Staphylococcus aureus
2.7.8.13 phospho-N-acetylmuramyl-pentapeptide translocase
-
 Enterococcus faecalis
2.7.8.13 translocase I
-
 Staphylococcus aureus
2.7.8.13 translocase I
-
 Enterococcus faecalis

General Information

EC Number General Information Comment Organism
2.7.8.13 physiological function translocase I is a key enzyme in peptidoglycan biosynthesis Staphylococcus aureus
2.7.8.13 physiological function translocase I is a key enzyme in peptidoglycan biosynthesis Enterococcus faecalis