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Literature summary extracted from

  • Sato, D.; Nozaki, T.
    Methionine gamma-lyase: the unique reaction mechanism, physiological roles, and therapeutic applications against infectious diseases and cancers (2009), IUBMB Life, 61, 1019-1028.
    View publication on PubMed

Application

EC Number Application Comment Organism
4.4.1.11 medicine utilization for the treatment of cancers Arabidopsis thaliana
4.4.1.11 medicine utilization for the treatment of cancers Entamoeba histolytica
4.4.1.11 medicine utilization for the treatment of cancers Pseudomonas putida
4.4.1.11 medicine utilization for the treatment of cancers Brevibacterium linens
4.4.1.11 medicine utilization for the treatment of cancers Fusobacterium nucleatum
4.4.1.11 medicine utilization for the treatment of cancers Porphyromonas gingivalis
4.4.1.11 medicine utilization for the treatment of cancers Prevotella denticola
4.4.1.11 medicine utilization for the treatment of cancers Trichomonas vaginalis

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.4.1.11
-
 Arabidopsis thaliana
4.4.1.11
-
 Entamoeba histolytica
4.4.1.11
-
 Pseudomonas putida
4.4.1.11
-
 Brevibacterium linens
4.4.1.11
-
 Fusobacterium nucleatum
4.4.1.11
-
 Porphyromonas gingivalis
4.4.1.11
-
 Prevotella denticola
4.4.1.11
-
 Trichomonas vaginalis

Protein Variants

EC Number Protein Variants Comment Organism
4.4.1.11 C116H increase of enzyme activity toward cysteine, decrease of enzyme activity toward methionine Pseudomonas putida

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.4.1.11 myrsinoic acid B
-
 Fusobacterium nucleatum
4.4.1.11 myrsinoic acid B
-
 Porphyromonas gingivalis
4.4.1.11 myrsinoic acid B
-
 Prevotella denticola

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.11 Arabidopsis thaliana
-
-
-
4.4.1.11 Brevibacterium linens
-
-
-
4.4.1.11 Entamoeba histolytica
-
-
-
4.4.1.11 Fusobacterium nucleatum
-
-
-
4.4.1.11 Porphyromonas gingivalis
-
-
-
4.4.1.11 Prevotella denticola
-
-
-
4.4.1.11 Pseudomonas putida
-
-
-
4.4.1.11 Trichomonas vaginalis O15564
-
-
4.4.1.11 Trichomonas vaginalis O15565
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.4.1.11 seed
-
 Arabidopsis thaliana
-

Synonyms

EC Number Synonyms Comment Organism
4.4.1.11 EhMGL1
-
 Entamoeba histolytica
4.4.1.11 EhMGL2
-
 Entamoeba histolytica
4.4.1.11 methionine gamma-lyase
-
 Arabidopsis thaliana
4.4.1.11 methionine gamma-lyase
-
 Entamoeba histolytica
4.4.1.11 methionine gamma-lyase
-
 Pseudomonas putida
4.4.1.11 methionine gamma-lyase
-
 Brevibacterium linens
4.4.1.11 methionine gamma-lyase
-
 Fusobacterium nucleatum
4.4.1.11 methionine gamma-lyase
-
 Porphyromonas gingivalis
4.4.1.11 methionine gamma-lyase
-
 Prevotella denticola
4.4.1.11 methionine gamma-lyase
-
 Trichomonas vaginalis
4.4.1.11 TvMGL1
-
 Trichomonas vaginalis
4.4.1.11 TvMGL2
-
 Trichomonas vaginalis

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
4.4.1.11 0.000389
-
-
 Fusobacterium nucleatum myrsinoic acid B
4.4.1.11 0.0303
-
-
 Prevotella denticola myrsinoic acid B
4.4.1.11 0.0824
-
-
 Porphyromonas gingivalis myrsinoic acid B

Expression

EC Number Organism Comment Expression
4.4.1.11 Arabidopsis thaliana higher expression in imbibed seeds up
4.4.1.11 Brevibacterium linens upregulation under methionine-rich conditions up

General Information

EC Number General Information Comment Organism
4.4.1.11 physiological function involvled in pathogenicity of periodontal bacterium Porphyromonas gingivalis
4.4.1.11 physiological function isoleucine biosynthesis, sulfur storage, involved in the alternative reverse-transsulfuration pathway, important roe in the resumption process Arabidopsis thaliana