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Literature summary extracted from

  • Fujii, S.; Toyama, A.; Amrein, H.
    A male-specific fatty acid omega-hydroxylase, SXE1, is necessary for efficient male mating in Drosophila melanogaster (2008), Genetics, 180, 179-190.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.15.3 cytoplasm in nonneuronal cells associated largely with sensory bristles Drosophila melanogaster 5737
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Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.15.3 58000
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 Western blot analysis Drosophila melanogaster

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.3 Drosophila melanogaster
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-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.15.3 antenna second antennal segment, only males Drosophila melanogaster
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1.14.15.3 eye in the vibrissae, ventral outside edge of compound eyes, only males Drosophila melanogaster
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1.14.15.3 head at the base of machrochaetae, only males Drosophila melanogaster
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1.14.15.3 additional information SXE1 protein expression is restricted to nonneuronal cells associated with diverse sensory bristles of both the chemo- and mechanosensory systems. Is present in labial palps and tips of maxillary palps in males and females, and in the base of bristles of the forelegs and the base of arista of males Drosophila melanogaster
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1.14.15.3 thorax
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 Drosophila melanogaster
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.3 fatty acid + NAD(P)H + H+ + O2
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 Drosophila melanogaster omega-hydroxy fatty acid + NAD(P)+ + H2O
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 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.15.3 CYP4d21
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 Drosophila melanogaster
1.14.15.3 male-specific fatty acid omega-hydroxylase
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 Drosophila melanogaster
1.14.15.3 sex-specific enzyme 1
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 Drosophila melanogaster
1.14.15.3 SXE1
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 Drosophila melanogaster

Expression

EC Number Organism Comment Expression
1.14.15.3 Drosophila melanogaster in the female labial palps, expression is weaker and restricted to a smaller area when compared to males down
1.14.15.3 Drosophila melanogaster similar to sxe1 mRNA, expression of SXE1 protein in males oscillates in a diurnal fashion, with highest protein levels occurring around midnight up

General Information

EC Number General Information Comment Organism
1.14.15.3 malfunction suppression or knockout of sxe1 significantly reduces mating success in males throughout the diurnal cycle Drosophila melanogaster
1.14.15.3 metabolism the metabolomic profile of wild-type and sxe1 mutant males reveals that sxe1 likely functions as a fatty acid omega-hydroxylase, suggesting that male courtship and mating success is mediated by small compounds generated by this enzyme Drosophila melanogaster
1.14.15.3 physiological function SXE1 is necessary for efficient male mating. Male-specific transcriptional regulator DSX(M) and the clock genes are necessary for cycling of sxe1 mRNA during the diurnal cycle Drosophila melanogaster