Literature summary extracted from

Montalban, A.G.; Boman, E.; Chang, C.D.; Ceide, S.C.; Dahl, R.; Dalesandro, D.; Delaet, N.G.; Erb, E.; Ernst, J.; Gibbs, A.; Kahl, J.; Kessler, L.; Lundstroem, J.; Miller, S.; Nakanishi, H.; Roberts, E.; Saiah, E.; Sullivan, R.; Wang, Z.; Larson, C.J.
KR-003048, a potent, orally active inhibitor of p38 mitogen-activated protein kinase (2010), Eur. J. Pharmacol., 632, 93-102.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
2.7.11.24	interleukin-I	-	Homo sapiens
2.7.11.24	lipopolysaccharide	-	Homo sapiens
2.7.11.24	additional information	activated by growth factors, cellular stresses, and cytokines	Homo sapiens
2.7.11.24	tumor necrosis factor-alpha	-	Homo sapiens

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
2.7.11.24	-	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.7.11.24	5-tert-butyl-N-cyclopropyl-2-methoxy-3-[2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetylamino]-benzamide	KR-003048	Homo sapiens
2.7.11.24	BIRB796	-	Homo sapiens
2.7.11.24	SB203580	-	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.7.11.24	ATP + a protein	Homo sapiens	-	ADP + a phosphoprotein	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.11.24	Homo sapiens	-	-	-

Posttranslational Modification

EC Number	Posttranslational Modification	Comment	Organism
2.7.11.24	phosphoprotein	-	Homo sapiens

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.7.11.24	blood	-	Homo sapiens	-
2.7.11.24	THP-1 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.7.11.24	ATP + a protein	-	Homo sapiens	ADP + a phosphoprotein	-	?
2.7.11.24	ATP + myelin basic protein	substrate in in vitro kinase assay	Homo sapiens	ADP + phosphorylated myelin basic protein	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.7.11.24	MAP kinase	-	Homo sapiens
2.7.11.24	mitogen-activated kinase	-	Homo sapiens
2.7.11.24	p38 mitogen-activated protein kinase	-	Homo sapiens
2.7.11.24	p38alpha	-	Homo sapiens

Temperature Optimum [°C]

EC Number	Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
2.7.11.24	25	-	kinase assay	Homo sapiens

pH Optimum

EC Number	pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
2.7.11.24	7.4	-	kinase assay	Homo sapiens

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
2.7.11.24	ATP	-	Homo sapiens

IC50 Value

EC Number	IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
2.7.11.24	0.000022	-	-	Homo sapiens	5-tert-butyl-N-cyclopropyl-2-methoxy-3-[2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetylamino]-benzamide
2.7.11.24	0.000033	-	-	Homo sapiens	SB203580
2.7.11.24	0.000035	-	-	Homo sapiens	BIRB796

General Information

EC Number	General Information	Comment	Organism
2.7.11.24	physiological function	monocyte, macrophage production of tumor necrosis factor-alpha is largely driven by p38 mitogen-activated protein kinase	Homo sapiens

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Release 2023.1 (January 2023)